A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2741-3. doi: 10.1016/s0960-894x(00)00576-x.

Abstract

A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cross-Linking Reagents
  • Diamines / chemical synthesis
  • Diamines / metabolism
  • Ligands
  • Polymers
  • Protein Binding
  • Rats
  • Receptors, Adrenergic / metabolism
  • Receptors, Dopamine / metabolism
  • Selective Serotonin Reuptake Inhibitors / chemical synthesis*
  • Selective Serotonin Reuptake Inhibitors / metabolism*
  • Structure-Activity Relationship
  • Synaptosomes / metabolism

Substances

  • Cross-Linking Reagents
  • Diamines
  • Ligands
  • Polymers
  • Receptors, Adrenergic
  • Receptors, Dopamine
  • Serotonin Uptake Inhibitors