Abstract
A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Cross-Linking Reagents
-
Diamines / chemical synthesis
-
Diamines / metabolism
-
Ligands
-
Polymers
-
Protein Binding
-
Rats
-
Receptors, Adrenergic / metabolism
-
Receptors, Dopamine / metabolism
-
Selective Serotonin Reuptake Inhibitors / chemical synthesis*
-
Selective Serotonin Reuptake Inhibitors / metabolism*
-
Structure-Activity Relationship
-
Synaptosomes / metabolism
Substances
-
Cross-Linking Reagents
-
Diamines
-
Ligands
-
Polymers
-
Receptors, Adrenergic
-
Receptors, Dopamine
-
Serotonin Uptake Inhibitors