BindingDB PrimarySearch

Found 127 with Last Name = 'hefnawy' and Initial = 'a'

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

IC50: 1nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 3nMAssay Description:Inhibition of human full length His-tagged PDE5A1 expressed in baculovirus infected Sf9 insect cells using [3H]-cGMP as substrate preincubated for 15...More data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566443(CHEMBL4879176)

IC50: 4nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 4.90nMAssay Description:Inhibition of human PDE5A1 catalytic domain (Glu535 to Gln860 residues) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate preincubated ...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566440(CHEMBL4863072)

IC50: 20nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566438(CHEMBL4852714)

IC50: 21nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566437(CHEMBL4867870)

IC50: 29nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566439(CHEMBL4869439)

IC50: 40nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566422(CHEMBL4863208)

IC50: 60nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566433(CHEMBL4857957)

IC50: 78nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566421(CHEMBL4866138)

IC50: 90nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566434(CHEMBL4874482)

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566416(CHEMBL4866415)

IC50: 130nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566444(CHEMBL4875037)

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566442(CHEMBL4867514)

IC50: 190nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566424(CHEMBL4849051)

IC50: 200nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566436(CHEMBL4871501)

IC50: 260nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566431(CHEMBL4856330)

IC50: 280nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566413(CHEMBL4858922)

IC50: 330nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566432(CHEMBL4861917)

IC50: 340nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566427(CHEMBL4865827)

IC50: 410nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566430(CHEMBL4878604)

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566411(CHEMBL4863021)

IC50: 500nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566417(CHEMBL4847766)

IC50: 590nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566428(CHEMBL4855088)

IC50: 600nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566420(CHEMBL4855752)

IC50: 900nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566426(CHEMBL4848935)

IC50: 1.16E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566415(CHEMBL4851670)

IC50: 1.19E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566429(CHEMBL4869663)

IC50: 1.20E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM54632(4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol...)

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566441(CHEMBL4864616)

IC50: 1.29E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566425(CHEMBL4847435)

IC50: 1.44E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566412(CHEMBL4851988)

IC50: 1.56E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM236641(US9388139, 9)

IC50: 1.80E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM236634(US9388139, 1)

IC50: 2.00E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566414(CHEMBL4846363)

IC50: 2.50E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM236658(US9388139, 27)

IC50: 3.10E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM236640(US9388139, 8)

IC50: 3.20E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM236642(US9388139, 10)

IC50: 6.90E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM236654(US9388139, 23)

IC50: 8.40E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566438(CHEMBL4852714)

IC50: 9.54E+3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE2A (unknown origin) expressed in baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566418(CHEMBL4864814)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566423(CHEMBL4856910)

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566432(CHEMBL4861917)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length GST-tagged PDE1A (unknown origin) expressed in baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566435(CHEMBL4872902)

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566438(CHEMBL4852714)

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566439(CHEMBL4869439)

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566443(CHEMBL4879176)

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

BDBM50566432(CHEMBL4861917)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length GST-tagged PDE1A (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as substr...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 127 total ) | Next | Last >>

Filter my 127 hits

Targets 11▿
- cGMP-specific 3',5'-cyclic phosphodiesterase 52
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 10
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 10
- cGMP-dependent 3',5'-cyclic phosphodiesterase 10
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 10
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 5
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 5
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 5
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 5
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 5
Publications 1▿
- J Med Chem 64: 4462-4477 (2021) 127
Institutions 1▿
- German University In Cairo 127
Affinity: 1 to 1.0E+6 nM▿
- IC50 122
- EC50 5
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 3
Catalog Cmpds: 4