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Found 5096 with Last Name = 'nakamura' and Initial = 'a'
TargetMu-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50245893((1'S,2S,5'S,13'R,17'S)-4'-(cyclopropylmethyl)-10',...)
Affinity DataKi:  4.54nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50245893((1'S,2S,5'S,13'R,17'S)-4'-(cyclopropylmethyl)-10',...)
Affinity DataKi:  4.82nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50245893((1'S,2S,5'S,13'R,17'S)-4'-(cyclopropylmethyl)-10',...)
Affinity DataKi:  8.66nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50245894(CHEMBL461313 | N-{[(1R,9S,10S,13R)-17-(cyclopropyl...)
Affinity DataIC50:  0.288nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.303nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50245894(CHEMBL461313 | N-{[(1R,9S,10S,13R)-17-(cyclopropyl...)
Affinity DataIC50:  0.303nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649820(US20240043403, Example 57)
Affinity DataIC50:  0.420nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataIC50:  0.650nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649819(US20240043403, Example 56)
Affinity DataIC50:  0.890nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50261457(17-(Cyclopropylmethyl)-4,6alpha-epoxymethanomorphi...)
Affinity DataIC50:  0.980nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  1.14nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50261457(17-(Cyclopropylmethyl)-4,6alpha-epoxymethanomorphi...)
Affinity DataIC50:  1.21nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in ICR mouse whole brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  1.27nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in ICR mouse whole brainMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellumMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649841(US20240043403, Example 78)
Affinity DataIC50:  1.30nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649857(US20240043403, Example 94)
Affinity DataIC50:  1.40nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649881(US20240043403, Example 118)
Affinity DataIC50:  1.40nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649849(US20240043403, Example 125 | US20240043403, Exampl...)
Affinity DataIC50:  1.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50097721(CHEMBL1879790 | EN300-11843)
Affinity DataIC50:  2nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50245894(CHEMBL461313 | N-{[(1R,9S,10S,13R)-17-(cyclopropyl...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649847(US20240043403, Example 84)
Affinity DataIC50:  2.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649856(US20240043403, Example 93)
Affinity DataIC50:  2.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649849(US20240043403, Example 125 | US20240043403, Exampl...)
Affinity DataIC50:  2.90nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273013(CHEMBL4129456)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649797(US20240043403, Example 34)
Affinity DataIC50:  3.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649809(US20240043403, Example 46)
Affinity DataIC50:  3.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649792(US20240043403, Example 122 | US20240043403, Exampl...)
Affinity DataIC50:  3.20nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649846(US20240043403, Example 83)
Affinity DataIC50:  3.5nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649811(US20240043403, Example 124 | US20240043403, Exampl...)
Affinity DataIC50:  3.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649858(US20240043403, Example 95)
Affinity DataIC50:  3.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649810(US20240043403, Example 123 | US20240043403, Exampl...)
Affinity DataIC50:  4nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649801(US20240043403, Example 38)
Affinity DataIC50:  4.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649850(US20240043403, Example 87)
Affinity DataIC50:  4.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649883(US20240043403, Example 120)
Affinity DataIC50:  4.30nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649796(US20240043403, Example 33)
Affinity DataIC50:  4.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649792(US20240043403, Example 122 | US20240043403, Exampl...)
Affinity DataIC50:  4.90nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649804(US20240043403, Example 41)
Affinity DataIC50:  5nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649803(US20240043403, Example 40)
Affinity DataIC50:  5.20nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649848(US20240043403, Example 85)
Affinity DataIC50:  5.20nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649840(US20240043403, Example 77)
Affinity DataIC50:  5.60nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649811(US20240043403, Example 124 | US20240043403, Exampl...)
Affinity DataIC50:  5.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649808(US20240043403, Example 126 | US20240043403, Exampl...)
Affinity DataIC50:  6.20nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDelta-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataIC50:  6.41nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in ICR mouse whole brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataIC50:  6.41nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649810(US20240043403, Example 123 | US20240043403, Exampl...)
Affinity DataIC50:  6.70nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649825(US20240043403, Example 62)
Affinity DataIC50:  6.90nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649861(US20240043403, Example 98)
Affinity DataIC50:  7.5nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649869(US20240043403, Example 106)
Affinity DataIC50:  7.5nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649839(US20240043403, Example 76)
Affinity DataIC50:  7.60nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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