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Found 101 with Last Name = 'ma' and Initial = 'bb'
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50589230(CHEMBL5181634)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-2MesADP from human P2Y12 in HEK cell membrane assessed as inhibition constant incubated for 1 hr by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50298132((4S)4-[({4-[4-(Methoxymethyl)piperidin-1-yl]-6-phe...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to P2Y12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50397143(CHEMBL2172140)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to P2Y12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50589229(CHEMBL5203993)
Affinity DataKi:  9nMAssay Description:Displacement of [33P]-2MeS-ADP from recombinant human P2Y12 transfected in HEK cell membrane assessed as inhibition constant incubated for 1 hr by co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50397204(ELINOGREL)
Affinity DataKi:  23nMAssay Description:Binding affinity to P2Y12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50268877(CHEMBL455536 | Disodium 1-Amino-4-[4-phenylamino-3...)
Affinity DataKi:  25nMAssay Description:Binding affinity to P2Y12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50118242(((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-2MesADP from recombinant human P2Y12 transfected in HEK cell membrane assessed as inhibition constantMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50118225(ARL 69931MX | Adenosine triphosphate derivative | ...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of P2Y12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetDihydrofolate reductase(Homo sapiens (Human))
Capital Normal University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human dihydrofolate reductase by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50397205(AR-C126532XX | AZD-6140 | AZD6140 | BRILINTA | TIC...)
Affinity DataIC50:  10nMAssay Description:Inhibition of P2Y12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003386(2-Ethyl-5-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003392(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50100247(CHEMBL3325891)
Affinity DataIC50:  17nMAssay Description:Inhibition of P2Y12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50406795(Cozaar | LOSARTAN POTASSIUM)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003400(2-Ethyl-6-methoxy-4-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003377(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003403(2-Ethyl-6-isopropoxy-4-[2'-(1H-tetrazol-5-yl)-biph...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003387(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003394(2-Methyl-4-{1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003376(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003398(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  66nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003382(2-Ethyl-6-(2-fluoro-ethoxy)-4-[2'-(1H-tetrazol-5-y...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50005340(2-Butyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  96nMAssay Description:Concentration required for 50% displacement of the specifically bound [3-[125I]-iodotyrosyl]-angiotensin II from angiotensin II receptor in the membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003404(5-Chloro-2-ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003380(2-Ethyl-7-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003384(8-Chloro-2-ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003395(7-Chloro-2-ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003381(4'-(2-Ethyl-quinolin-4-yloxymethyl)-biphenyl-2-car...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003378(4'-(2-Methyl-quinolin-4-yloxymethyl)-biphenyl-2-ca...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003379(2-Ethyl-7-methoxy-4-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  220nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Capital Normal University

Curated by ChEMBL
LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant His-tagged thymidylate synthase assessed as N5,N10-methylenetetrahydrofolate oxidation to dihydrofolate after 20 mins...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003391(2-Methyl-4-{2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003389(2,8-Dimethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003402(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  360nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003406(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  370nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003399(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Affinity DataIC50:  430nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003390(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  460nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003374(2,6-Dimethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  470nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003399(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Affinity DataIC50:  480nMAssay Description:Concentration required for 50% displacement of the specifically bound [3-[125I]-iodotyrosyl]-angiotensin II from angiotensin II receptor in the membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003393(4'-(2-Propyl-quinolin-4-yloxymethyl)-biphenyl-2-ca...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50230428(CHEMBL352376)
Affinity DataIC50:  640nMAssay Description:Inhibition of [3-[125I]-iodotyrosyl]-angiotensin II binding to Angiotensin II receptors in the membrane preparations of guinea pig adrenal glands.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50230436(CHEMBL424372)
Affinity DataIC50:  860nMAssay Description:Inhibition of [3-[125I]-iodotyrosyl]-angiotensin II binding to Angiotensin II receptors in the membrane preparations of guinea pig adrenal glands.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003388(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  860nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003396(2-Ethyl-8-methoxy-4-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  960nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003375(6-Chloro-2-methyl-4-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50003397(2-Methyl-4-{2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50230438(CHEMBL171530)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of [3-[125I]-iodotyrosyl]-angiotensin II binding to Angiotensin II receptors in the membrane preparations of guinea pig adrenal glands.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Capital Normal University

Curated by ChEMBL
LigandPNGBDBM50434818(CHEMBL2387094)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of human dihydrofolate reductase by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50589231(CHEBI:87723 | Efient | LY-640315 | NSC-759625 | PR...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of P2Y12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50230439(CHEMBL172344)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of [3-[125I]-iodotyrosyl]-angiotensin II binding to Angiotensin II receptors in the membrane preparations of guinea pig adrenal glands.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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