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Found 45 with Last Name = 'willis' and Initial = 'c'
TargetAdenosine kinase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50100587((2R,3R,4S,5R)-2-(6-Amino-5-nitro-pyrimidin-4-ylami...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of adenosine kinase from undialyzed W1-L2 lysate (0-50 uM)Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50227263(CHEMBL2021376)
Affinity DataKi: <5.00E+3nMAssay Description:Inhibitory activity against purine nucleoside phosphorylase (PNPase )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50022506(5-Amino-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydr...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory activity against purine nucleoside phosphorylase (PNPase )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50367673(CHEMBL608050)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibitory activity against purine nucleoside phosphorylase (PNPase )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50022505(1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibitory activity against purine nucleoside phosphorylase (PNPase )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50367674(CHEMBL611275)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibitory activity against purine nucleoside phosphorylase (PNPase )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Nucleic Acid Research Institute

Curated by ChEMBL
LigandPNGBDBM50225889(CHEMBL3144008)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibitory activity against purine nucleoside phosphorylase (PNPase )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50589997(CHEMBL5208060)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50589997(CHEMBL5208060)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of recombinant Plasmodium falciparum GSK3 using GS-1 as substrate measured after 30 mins in presence of [gamma 32P-ATP] by SDS-PAGE based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM36336(CID24762166 | Purfalcamine, 1)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of Plasmodium falciparum CDPK1 measured after 2 hrs by luciferin based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant Plasmodium falciparum GSK3 using GS-1 as substrate measured after 30 mins in presence of [gamma 32P-ATP] by SDS-PAGE based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50:  23nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590019(CHEMBL5176863)
Affinity DataIC50:  79nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590018(CHEMBL5186081)
Affinity DataIC50:  97nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590015(CHEMBL5207951)
Affinity DataIC50:  124nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590014(CHEMBL5180806)
Affinity DataIC50:  165nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590017(CHEMBL5173813)
Affinity DataIC50:  172nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590013(CHEMBL5197512)
Affinity DataIC50:  174nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590004(CHEMBL5198648)
Affinity DataIC50:  223nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590001(CHEMBL5202515)
Affinity DataIC50:  226nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590002(CHEMBL5179526)
Affinity DataIC50:  243nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590005(CHEMBL5203707)
Affinity DataIC50:  272nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590000(CHEMBL5208765)
Affinity DataIC50:  308nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590003(CHEMBL5178028)
Affinity DataIC50:  328nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590012(CHEMBL5191618)
Affinity DataIC50:  456nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50424223(CHEMBL2313853)
Affinity DataIC50:  480nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50424223(CHEMBL2313853)
Affinity DataIC50:  480nMAssay Description:Inhibition of recombinant Plasmodium falciparum GSK3 using GS-1 as substrate measured after 30 mins in presence of [gamma 32P-ATP] by SDS-PAGE based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590010(CHEMBL5177833)
Affinity DataIC50:  490nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590009(CHEMBL5172803)
Affinity DataIC50:  550nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  570nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50589998(CHEMBL5185763)
Affinity DataIC50:  695nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590007(CHEMBL5203977)
Affinity DataIC50:  698nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590011(CHEMBL5201703)
Affinity DataIC50:  710nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  752nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50589999(CHEMBL5195159)
Affinity DataIC50:  810nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590006(CHEMBL5206250)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590008(CHEMBL5194800)
Affinity DataIC50:  1.14E+3nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590016(CHEMBL5194982)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50508732(CHEMBL4453990)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Southmead Hospital

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  6.00E+4nMAssay Description:Displacement of [125I]NGF from full length human TrkA expressed in HEKN3S cells cells by gamma counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Southmead Hospital

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataKd:  2.10E+6nMAssay Description:Binding affinity to V305 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Southmead Hospital

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataKd:  2.10E+6nMAssay Description:Binding affinity to C345 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Southmead Hospital

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataKd:  2.20E+6nMAssay Description:Binding affinity to F303 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Southmead Hospital

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataEC50:  8.60E+4nMAssay Description:Antagonist activity at full length glycosylated human TrkA expressed in HEKN3S cells cells assessed as reduction in NGF-induced ERK 42/44 phosphoryla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Southmead Hospital

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataKd:  1.80E+6nMAssay Description:Binding affinity to T292 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed