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Found 109 with Last Name = 'liu' and Initial = 'cy'
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11233(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  53nM ΔG°:  -41.5kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11232(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11231(N-[(benzyloxy)carbonyl]-L-valyl-N1-((1S,2E)-4-etho...)
Affinity DataKi:  660nM ΔG°:  -35.3kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11230(AG7088 analogue 2d | CHEMBL277716 | N-[(benzyloxy)...)
Affinity DataKi:  2.26E+3nM ΔG°:  -32.2kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11229(AG7088 analogue 2a | CHEMBL20636 | N-[(5-methyliso...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285592(CHEMBL4176214)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using KI 177 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285589(CHEMBL4159460)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using KI 177 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285589(CHEMBL4159460)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285592(CHEMBL4176214)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285591(CHEMBL4162183)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285591(CHEMBL4162183)
Affinity DataIC50:  11nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using KI 177 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285592(CHEMBL4176214)
Affinity DataIC50:  17nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells using KI 177 as substrate preincubated for 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase tousled-like 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50599378(CHEMBL5204542)
Affinity DataIC50:  19nMAssay Description:Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 stai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50:  29nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using KI 177 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285592(CHEMBL4176214)
Affinity DataIC50:  30nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged full length recombinant human HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127174(CHEMBL3628599)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285589(CHEMBL4159460)
Affinity DataIC50:  33nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells using KI 177 as substrate preincubated for 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase tousled-like 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50599379(CHEMBL5188455)
Affinity DataIC50:  33nMAssay Description:Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 stai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285589(CHEMBL4159460)
Affinity DataIC50:  35nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged full length recombinant human HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127173(CHEMBL3628598)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127164(CHEMBL3628597)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  64nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using KI 177 as subst...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285591(CHEMBL4162183)
Affinity DataIC50:  73nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged full length recombinant human HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  73nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged full length recombinant human HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127160(CHEMBL3628595)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127204(CHEMBL3628602)
Affinity DataIC50:  108nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50:  108nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged full length recombinant human HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285591(CHEMBL4162183)
Affinity DataIC50:  111nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells using KI 177 as substrate preincubated for 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127203(CHEMBL3628601)
Affinity DataIC50:  116nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127206(CHEMBL3628604)
Affinity DataIC50:  145nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase tousled-like 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50599380(CHEMBL5173181)
Affinity DataIC50:  163nMAssay Description:Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 stai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127158(CHEMBL3628593)
Affinity DataIC50:  167nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127175(CHEMBL3628600)
Affinity DataIC50:  176nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127161(CHEMBL3628596)
Affinity DataIC50:  181nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127205(CHEMBL3628603)
Affinity DataIC50:  209nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  214nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells using KI 177 as substrate preincubated for 5 min...More data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127159(CHEMBL3628594)
Affinity DataIC50:  312nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285592(CHEMBL4176214)
Affinity DataIC50:  398nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 (1 to 377 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285591(CHEMBL4162183)
Affinity DataIC50:  421nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 (1 to 377 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285589(CHEMBL4159460)
Affinity DataIC50:  561nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 (1 to 377 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127136(CHEMBL1442185)
Affinity DataIC50:  561nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127164(CHEMBL3628597)
Affinity DataIC50:  602nMAssay Description:Inhibition of recombinant human IDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127174(CHEMBL3628599)
Affinity DataIC50:  640nMAssay Description:Inhibition of recombinant human IDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50:  711nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50:  752nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 (1 to 377 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50:  767nMAssay Description:Inhibition of recombinant human IDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127155(CHEMBL3628554)
Affinity DataIC50:  768nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127136(CHEMBL1442185)
Affinity DataIC50:  809nMAssay Description:Inhibition of recombinant human IDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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