Compile Data Set for Download or QSAR
maximum 50k data
Found 3632 with Last Name = 'horne' and Initial = 'd'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99011(US8497265, 467)
Affinity DataIC50:  0.200nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98900(US8497265, 226)
Affinity DataIC50:  0.229nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99013(US8497265, 469)
Affinity DataIC50:  0.300nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99009(US8497265, 465)
Affinity DataIC50:  0.300nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99048(US8497265, 688)
Affinity DataIC50:  0.390nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99010(US8497265, 466 | US8497265, 470)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98928(US8497265, 254)
Affinity DataIC50:  0.639nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383846(CHEMBL2031142)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383847(CHEMBL2031143)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-{4-[2-(2-hydro...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99052(US8497265, 736 | US8497265, 797)
Affinity DataIC50:  0.864nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99052(US8497265, 736 | US8497265, 797)
Affinity DataIC50:  0.864nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383838(CHEMBL2030996)
Affinity DataIC50:  1nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99012(US8497265, 468)
Affinity DataIC50:  1.10nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM25472(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Affinity DataIC50:  1.5nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98931(US8497265, 343)
Affinity DataIC50:  1.52nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98932(US8497265, 344)
Affinity DataIC50:  1.68nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397712(CHEMBL2181902)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397708(CHEMBL2181906)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383850(CHEMBL2030994)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383837(CHEMBL2030998)
Affinity DataIC50:  2nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383851(CHEMBL2031145)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383855(CHEMBL2031149)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252978((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-pyrrolidin-1-y...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.30nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM99037(US8497265, 677)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99037(US8497265, 677)
Affinity DataIC50:  2.90nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397707(CHEMBL2181907)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383854(CHEMBL2031148)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383839(CHEMBL2030997)
Affinity DataIC50:  3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99010(US8497265, 466 | US8497265, 470)
Affinity DataIC50:  3.10nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397697(CHEMBL2181917)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  3.30nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99008(US8497265, 464)
Affinity DataIC50:  3.30nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397688(CHEMBL2181896)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397709(CHEMBL2181905)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397706(CHEMBL2181908)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50259591(CHEMBL493656)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50259591(CHEMBL493656)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383856(CHEMBL2031150)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383838(CHEMBL2030996)
Affinity DataIC50:  4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383846(CHEMBL2031142)
Affinity DataIC50:  4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50383845(CHEMBL2031141)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Envoy Therapeutics

Curated by ChEMBL
LigandPNGBDBM50397692(CHEMBL2181892)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM99146(US8497265, 895)
Affinity DataIC50:  4.11nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Displayed 1 to 50 (of 3632 total ) | Next | Last >>
Jump to: