Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at rat CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at dog CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Actelion Pharmaceuticals
Curated by ChEMBL
Actelion Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL9 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at dog CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals
Curated by ChEMBL
Actelion Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human ERG K+ currents by GLP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary human T cells assessed as inhibition of CXCLI1 mediate...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at mouse CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary mouse T cells assessed as inhibition of CXCLI1 mediate...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Antagonist activity at CXCR3 in human whole blood assessed as receptor internalization incubated for 30 mins in presence of CXCL10 by flow cytometric...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair