Affinity DataKi: 1.5nMAssay Description:Binding affinity of the compound for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Binding affinity of the compound for NK-3 receptor was determined in vitro using isolated rat portal vein.More data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Binding affinity of the compound for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Binding affinity of the compound for NK-3 receptor was determined in vitro using isolated rat portal vein.More data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Binding affinity of the compound for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Binding affinity of the compound for NK-1 receptor was determined in vitro using isolated rabbit vena cava.More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Antagonistic potency for NK-1 receptor was determined in a radioligand binding assay, using IM9 human lymphoblastoma cell line.More data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
Affinity DataKi: 4.20E+3nMAssay Description:Binding affinity of the compound for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.560nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 0.700nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 0.800nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 0.800nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.10nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.10nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.20nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.30nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.30nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.30nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.40nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Janssen Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.40nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.5nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.5nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.5nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.60nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.60nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.60nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.60nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.60nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.60nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (αscreen) format (Perkin Elmer). All compounds tested were dissolv...More data for this Ligand-Target Pair