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Found 69 with Last Name = 'nesi' and Initial = 'g'
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50485931(CHEMBL2178999)
Affinity DataKi:  2.80E+3nMAssay Description:Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-inhibitor c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50485930(CHEMBL2179000)
Affinity DataKi:  3.40E+3nMAssay Description:Noncompetitive inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50485930(CHEMBL2179000)
Affinity DataKi:  3.40E+3nMAssay Description:Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-inhibitor c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50485930(CHEMBL2179000)
Affinity DataKi:  3.90E+3nMAssay Description:Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-substrate-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50485931(CHEMBL2178999)
Affinity DataKi:  4.60E+3nMAssay Description:Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-substrate-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50341243((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50184998(CHEMBL3823242)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185001(CHEMBL3824119 | US10351548, Compound IB35)
Affinity DataIC50:  112nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  272nMAssay Description:Inhibition of GSK3beta (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  274nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499155(CHEMBL3736436)
Affinity DataIC50:  310nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279007(CHEMBL4166349)
Affinity DataIC50:  340nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279006(CHEMBL4174650)
Affinity DataIC50:  356nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50278993(CHEMBL4166749)
Affinity DataIC50:  378nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  416nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279005(CHEMBL4170157)
Affinity DataIC50:  452nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279013(CHEMBL4176974)
Affinity DataIC50:  507nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279008(CHEMBL4173608)
Affinity DataIC50:  511nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185003(CHEMBL3824264 | US10351548, Compound JJ31)
Affinity DataIC50:  512nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279012(CHEMBL4162892)
Affinity DataIC50:  650nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50:  678nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  884nMAssay Description:Inhibition of GSK3alpha (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  980nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  998nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of 25 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50184999(CHEMBL3823622 | US10351548, Compound SA23)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185002(CHEMBL3822974 | US10351548, Compound IB32)
Affinity DataIC50:  6.68E+3nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499154(CHEMBL3735078)
Affinity DataIC50:  6.81E+3nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009031(CHEMBL3237950)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009050(CHEMBL3237951)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009051(CHEMBL3233062)
Affinity DataEC50:  300nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009052(CHEMBL3237952)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009053(CHEMBL3237953)
Affinity DataEC50:  900nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009054(CHEMBL3237954)
Affinity DataEC50:  7.10nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009055(CHEMBL3237955)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009056(CHEMBL3237956)
Affinity DataEC50:  3.25E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009058(CHEMBL3237957)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009059(CHEMBL3237958)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009060(CHEMBL3237959)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009062(CHEMBL3237960)
Affinity DataEC50:  1.15E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009064(CHEMBL3237961)
Affinity DataEC50:  1.09E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009065(CHEMBL3237962)
Affinity DataEC50:  4.37E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataEC50:  44nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM10758(14C-phenylethylamine | 2-phenylethan-1-amine | CHE...)
Affinity DataEC50:  138nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50359505(CHEMBL1182312)
Affinity DataEC50:  189nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50096963(CHEMBL3580902)
Affinity DataEC50:  240nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50096964(CHEMBL3580901)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50096965(CHEMBL3580905)
Affinity DataEC50:  800nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50096966(CHEMBL3580906)
Affinity DataEC50:  2.20E+3nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM10758(14C-phenylethylamine | 2-phenylethan-1-amine | CHE...)
Affinity DataEC50:  138nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293T cells assessed as induction of cAMP production by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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