Compile Data Set for Download or QSAR
maximum 50k data
Found 46 with Last Name = 'williams' and Initial = 'hw'
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016991(7-Fluoro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  7nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  11nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016990(2-(4-Methoxy-benzyl)-3,7-dimethyl-5-propyl-benzofu...)
Affinity DataIC50:  12nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017001(7-Chloro-2-(2,4-dimethoxy-benzyl)-3-methyl-5-propy...)
Affinity DataIC50:  13nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017000(5-Allyl-7-chloro-2-(4-methoxy-benzyl)-3-methyl-ben...)
Affinity DataIC50:  20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016987(7-Chloro-2-(4-methoxy-benzyl)-3,5-dipropyl-benzofu...)
Affinity DataIC50:  20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016998(7-Chloro-2-(4-chloro-benzyl)-3-methyl-5-propyl-ben...)
Affinity DataIC50:  26nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016994(2-Benzyl-7-chloro-3-methyl-5-propyl-benzofuran-4-o...)
Affinity DataIC50:  30nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016985(2-(4-Methoxy-benzyl)-3-methyl-5-propyl-benzofuran-...)
Affinity DataIC50:  31nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  36nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016989(7-Chloro-2-(4-methoxy-benzyl)-3,5-dimethyl-benzofu...)
Affinity DataIC50:  46nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50404997(CHEMBL18295)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405004(CHEMBL282504)
Affinity DataIC50:  63nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016992(7-Chloro-5-(3-hydroxy-propyl)-2-(4-methoxy-benzyl)...)
Affinity DataIC50:  76nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  85nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405001(CHEMBL273783)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016997(5-tert-Butyl-7-chloro-2-(4-methoxy-benzyl)-3-methy...)
Affinity DataIC50:  99nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017002(CHEMBL18559 | [4-(7-Chloro-4-hydroxy-3-methyl-5-pr...)
Affinity DataIC50:  105nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016991(7-Fluoro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  129nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016985(2-(4-Methoxy-benzyl)-3-methyl-5-propyl-benzofuran-...)
Affinity DataIC50:  130nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405003(CHEMBL428525)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016990(2-(4-Methoxy-benzyl)-3,7-dimethyl-5-propyl-benzofu...)
Affinity DataIC50:  140nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405007(CHEMBL18721)
Affinity DataIC50:  160nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016992(7-Chloro-5-(3-hydroxy-propyl)-2-(4-methoxy-benzyl)...)
Affinity DataIC50:  161nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50404998(CHEMBL276330)
Affinity DataIC50:  180nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016993(7-Chloro-5-ethoxymethyl-2-(4-methoxy-benzyl)-3-met...)
Affinity DataIC50:  291nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016999(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-benzofuran-...)
Affinity DataIC50:  376nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405002(CHEMBL19036)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase reaction catalyzed by purified enzyme from porcine leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405010(CHEMBL18672)
Affinity DataIC50:  440nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016988(2-(4-Methoxy-benzyl)-3-methyl-benzofuran-4-ol | CH...)
Affinity DataIC50:  574nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50404999(CHEMBL282502)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016996(5,7-Dichloro-2-(4-methoxy-benzyl)-3-methyl-benzofu...)
Affinity DataIC50:  860nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50152559(4-Biphenyl-4-yl-2,4-dioxo-butyric acid | CHEMBL182...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405000(CHEMBL18773)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405005(CHEMBL279530)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016999(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-benzofuran-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016988(2-(4-Methoxy-benzyl)-3-methyl-benzofuran-4-ol | CH...)
Affinity DataIC50:  2.07E+3nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405009(CHEMBL19028)
Affinity DataIC50:  2.10E+3nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016995(3-[7-Chloro-4-hydroxy-2-(4-methoxy-benzyl)-3-methy...)
Affinity DataIC50:  2.13E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50125793(4-(4-Cyclohexyl-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50:  3.00E+3nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  9.20E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405006(CHEMBL275811)
Affinity DataIC50:  1.90E+4nMAssay Description:In vitro inhibition of porcine Glycolate oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory activity of the compound towards soybean lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of partially purified 15-lipoxygenase from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Sus scrofa)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory activity of the compound towards porcine 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed