Compile Data Set for Download or QSAR
maximum 50k data
Found 542 with Last Name = 'nash' and Initial = 'i'
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50263028(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7657(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50025069(CHEMBL485425)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50025068(CHEMBL484555)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7672(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274698(4-(4-(1-ethyl-2-methyl-1H-imidazol-5-yl)pyrimidin-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50315949((S)-N-(4-aminobutyl)-N-(2-(1-phenylethylamino)pyri...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human p38alpha assessed as gamma-[32P]ATP incorporation after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384389(CHEMBL2031461)
Affinity DataIC50:  4.68nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human wh...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274662(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Cyclin E/CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50306491(2-(6-chloro-5-((2R,5S)-4-(1-(4-fluorophenyl)ethyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384389(CHEMBL2031461)
Affinity DataIC50:  6.61nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384389(CHEMBL2031461)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7674(CHEMBL484571 | Imidazo[1,2-b]pyridazine deriv. 2d ...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274661(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274625(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(pr...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384364(CHEMBL2031462)
Affinity DataIC50:  8.13nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384385(CHEMBL2031238)
Affinity DataIC50:  8.91nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384385(CHEMBL2031238)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50306493(2-(5-((2R,5S)-4-benzhydryl-2,5-dimethylpiperazine-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384382(CHEMBL2031227)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384382(CHEMBL2031227)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50026697(CHEMBL1940287)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human MMP13 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50309525(2-(5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)-6-m...)
Affinity DataIC50:  10nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274626(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50315959(CHEMBL1091614 | N-(4-aminobutyl)-N-(2-(4-hydroxycy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human p38alpha assessed as gamma-[32P]ATP incorporation after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384389(CHEMBL2031461)
Affinity DataIC50:  11nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384364(CHEMBL2031462)
Affinity DataIC50:  11nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384389(CHEMBL2031461)
Affinity DataIC50:  11.2nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384364(CHEMBL2031462)
Affinity DataIC50:  11.5nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7659(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)
Affinity DataIC50: <12nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50026717(CHEMBL1940278)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human MMP13 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274806(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-((t...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50315931((S)-N-ethyl-3-methyl-N-(2-(1-phenylethylamino)pyri...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human p38alpha assessed as gamma-[32P]ATP incorporation after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274805(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(2-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384365(CHEMBL2031229)
Affinity DataIC50:  14nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384365(CHEMBL2031229)
Affinity DataIC50:  14.1nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274699(4-(4-(1-isobutyl-2-methyl-1H-imidazol-5-yl)pyrimid...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384378(CHEMBL2031222)
Affinity DataIC50:  15nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384378(CHEMBL2031222)
Affinity DataIC50:  15.1nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384385(CHEMBL2031238)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human wh...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetG2/mitotic-specific cyclin-B1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Cyclin B1/CDK1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50:  16nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50315917((S)-N-ethyl-N-(2-(1-phenylethylamino)pyrimidin-4-y...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human p38alpha assessed as gamma-[32P]ATP incorporation after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50315958(CHEMBL1089655 | N-(4-aminobutyl)-N-(2-(isopropylam...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human p38alpha assessed as gamma-[32P]ATP incorporation after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50:  17.4nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human wh...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Scios

Curated by ChEMBL
LigandPNGBDBM50153846(4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...)
Affinity DataIC50:  18nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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