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Found 1323 with Last Name = 'ma' and Initial = 'mg'
LigandPNGBDBM50170654((+-)-cis-4-(3-(4-tert-butylphenyl)-2-methylpropyl)...)
Affinity DataKi:  0.0110nMAssay Description:Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50248926(3-((1-(4-chlorobenzyl)piperidin-4-yl)methyl)benzo[...)
Affinity DataKi:  0.0980nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50248926(3-((1-(4-chlorobenzyl)piperidin-4-yl)methyl)benzo[...)
Affinity DataKi:  0.0980nMAssay Description:Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataKi:  0.300nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183549((S)-(+)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183539(CHEMBL381256 | CHEMBL429492 | trans-(R,R)-4-[2-[bi...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183535((R)-(+)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50047016(1-(4-Fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromet...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183540((S)-(-)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183545(CHEMBL444540 | R-(-)-4-[2-[bis-(4-fluorophenyl)met...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193455(CHEMBL3966143)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183532(4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1-(3,4-di...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50310078((R/S)-1-(3-(6-Methoxynaphthalen-2-yl)butyl)piperid...)
Affinity DataKi:  1.29nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 opioid receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183546(CHEMBL383071 | S-(+)-4-[2-[bis-(4-fluorophenyl)met...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183547(CHEMBL206128 | CHEMBL255065 | trans-(S,S)-4-[2-[bi...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183538((R)-(+)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]DA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183548((S)-(+)-4-(2-benzhydryloxyethyl)-1-(3-phenylpropan...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502547(CHEMBL4581662)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes in the presence of sigma1 receptor ligand (+)-pentazocine incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183542((S)-(-)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183543((R)-(-)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of [3H]DA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183550((R)-(+)-4-(2-benzhydryloxyethyl)-1-(3-phenylpropan...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380360(CHEMBL2017957)
Affinity DataKi:  1.87nMAssay Description:Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502547(CHEMBL4581662)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183538((R)-(+)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183546(CHEMBL383071 | S-(+)-4-[2-[bis-(4-fluorophenyl)met...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [3H]DA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183533((S)-(-)-4-(2-benzhydryloxyethyl)-1-(3-phenylpropan...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183541(CHEMBL424682 | R-(-)-4-[2-[bis-(4-fluorophenyl)met...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]RTI-55 from DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50310077((R/S)-N-Benzyl-3-(6-methoxynaphthalen-2-yl)-N-meth...)
Affinity DataKi:  2.31nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 opioid receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50310074((R/S)-4-(benzyl(methyl)amino)-2-(biphenyl-4-yl)but...)
Affinity DataKi:  2.38nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 opioid receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50370067(CHEMBL1237164)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to DOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM50295408(3-[4-(N-Benzyl-N-methylamino)butyl]benzo[d]oxazol-...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50295408(3-[4-(N-Benzyl-N-methylamino)butyl]benzo[d]oxazol-...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193445(CHEMBL3964384)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193443(CHEMBL3954990)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50248955(3-((1-(4-methylbenzyl)piperidin-4-yl)methyl)benzo[...)
Affinity DataKi:  3.07nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027065((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50248905(3-((1-benzylpiperidin-4-yl)methyl)benzo[d]oxazol-2...)
Affinity DataKi:  3.58nMAssay Description:Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50248905(3-((1-benzylpiperidin-4-yl)methyl)benzo[d]oxazol-2...)
Affinity DataKi:  3.58nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50198062((R/S)-N-Benzyl-3-(biphenyl-4-yl)-N-methylbutan-1-a...)
Affinity DataKi:  3.59nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 opioid receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50062556(CHEMBL3397622)
Affinity DataKi:  3.70nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain cortex sigma1 receptor by scintillation analyzerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50183544(CHEMBL202644 | S-(+)-4-[2-[bis-(4-fluorophenyl)met...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of [3H]DA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027065((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50198065(4(E)-N-Benzyl-3-(biphenyl-4-yl)-N-methylbut-2-en-1...)
Affinity DataKi:  4.17nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 opioid receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50310076((E)-1-(3-(6-Methoxynaphthalen-2-yl)but-2-enyl)pipe...)
Affinity DataKi:  4.41nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 opioid receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50062557(CHEMBL3397621)
Affinity DataKi:  4.60nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain cortex sigma1 receptor by scintillation analyzerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50001028((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502554(CHEMBL4533030)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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