Compile Data Set for Download or QSAR
maximum 50k data
Found 625 with Last Name = 'kelly' and Initial = 'mj'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169690(CHEMBL3806137)
Affinity DataKi:  540nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50145198(CHEMBL3765778)
Affinity DataKi:  1.90E+3nMAssay Description:Positive allosteric modulation of 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50145198(CHEMBL3765778)
Affinity DataKi:  2.00E+3nMAssay Description:Positive allosteric modulation of platelet-activating factor receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621933((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...)
Affinity DataIC50:  0.200nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630994((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...)
Affinity DataIC50:  0.200nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630994((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...)
Affinity DataIC50:  0.200nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621932((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...)
Affinity DataIC50:  0.200nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621910((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5-chlo...)
Affinity DataIC50:  0.400nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621911((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5-chlo...)
Affinity DataIC50:  0.400nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621824((S)-N-((R or S)-(4- chlorophenyl)(4- fluoro-3-(tri...)
Affinity DataIC50:  0.600nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630957((S)-N-((R or S)-(4- chlorophenyl)(4- fluoro-3-(tri...)
Affinity DataIC50:  0.600nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621909((S)-N-(bis(3-chloro-4- fluorophenyl)methyl)- 2-oxo...)
Affinity DataIC50:  0.700nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621909((S)-N-(bis(3-chloro-4- fluorophenyl)methyl)- 2-oxo...)
Affinity DataIC50:  0.700nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621868((S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(5-...)
Affinity DataIC50:  1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630953((S)-N-((R or S)-(3- choro-4-fluoro- phenyl)(2-(1- ...)
Affinity DataIC50:  1.10nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630941((4S)-N-[((R or S)-5- chloro-6-cyclo- propylpyridin...)
Affinity DataIC50:  1.10nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621746(BDBM621803 | US11802122, Example 7A | US2023031252...)
Affinity DataIC50:  1.10nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621746(BDBM621803 | US11802122, Example 7A | US2023031252...)
Affinity DataIC50:  1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621816((4S)-N-[((R or S)-5- chloro-6-cyclo- propylpyridin...)
Affinity DataIC50:  1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621822((S)-N-((R or S)-(3- choro-4-fluoro- phenyl)(2-(1- ...)
Affinity DataIC50:  1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621868((S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(5-...)
Affinity DataIC50:  1.10nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621869((S)-N-((R)-3-chloro-4-(trifluoromethoxy)phenyl)(5-...)
Affinity DataIC50:  1.30nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM631027((S)—N—((R)-(3-chloro-2,4-difluorophenyl)...)
Affinity DataIC50:  1.30nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621859((S)-N-((R)-(3-chloro-2,4-difluorophenyl)(6-(2,2,2-...)
Affinity DataIC50:  1.30nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM631047((S)—N—((R)-3-chloro-4-(trifluoromethoxy)...)
Affinity DataIC50:  1.30nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621743(BDBM621800 | US11802122, Example 5A | US2023031252...)
Affinity DataIC50:  1.60nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621743(BDBM621800 | US11802122, Example 5A | US2023031252...)
Affinity DataIC50:  1.60nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621873((S)—N—((R)-(3-chloro-4-(trifluoromethoxy...)
Affinity DataIC50:  1.70nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM631055((S)—N—((R)-(3-chloro-4-(trifluoromethoxy...)
Affinity DataIC50:  1.70nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621808((S)-N-((R)-(3-chlorophenyl)(4-(trifluoromethoxy)ph...)
Affinity DataIC50:  2nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630925((S)—N—((R)-(3-chlorophenyl)(4-(trifluoro...)
Affinity DataIC50:  2nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630925((S)—N—((R)-(3-chlorophenyl)(4-(trifluoro...)
Affinity DataIC50:  2nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621809((S)-N-((R)-(3-chlorophenyl)(4-(trifluoromethoxy)ph...)
Affinity DataIC50:  2nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621900((S)-N-((R or S)-(4- chloro-3- cyanophenyl)(4- (tri...)
Affinity DataIC50:  2.40nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621900((S)-N-((R or S)-(4- chloro-3- cyanophenyl)(4- (tri...)
Affinity DataIC50:  2.40nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621818((4S)-N-{[(R or S)-5- chloro-6-(trifluoro- methyl)p...)
Affinity DataIC50:  2.40nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM631035((S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(2-...)
Affinity DataIC50:  2.40nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630945((4S)-N-{[(R or S)-5- chloro-6-(trifluoro- methyl)p...)
Affinity DataIC50:  2.40nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621863((S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(2-...)
Affinity DataIC50:  2.40nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM630924((S)-N-((R or S)-(5- chloro-6- (trifluoromethyl)pyr...)
Affinity DataIC50:  2.5nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621897((S)-N-((R or S)-(5- chloro-6- (trifluoromethyl)pyr...)
Affinity DataIC50:  2.5nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621870((S)—N—((R)-3-chloro-4-(trifluoromethoxy)...)
Affinity DataIC50:  2.5nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM631047((S)—N—((R)-3-chloro-4-(trifluoromethoxy)...)
Affinity DataIC50:  2.5nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621739(BDBM621797 | US11802122, Example 3A | US2023031252...)
Affinity DataIC50:  2.70nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621796((S)-N-((R)-(5-chloro-6-(difluoromethyl)pyridin-2-y...)
Affinity DataIC50:  2.70nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621965((S)-N-((R or S)- benzo[d]thiazol-2- yl(3-chloro-4-...)
Affinity DataIC50:  2.90nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621965((S)-N-((R or S)- benzo[d]thiazol-2- yl(3-chloro-4-...)
Affinity DataIC50:  2.90nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM621877((S)-N-((R or S)-(3- chloro-2,4-difluoro- phenyl)(5...)
Affinity DataIC50:  3.10nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Displayed 1 to 50 (of 625 total ) | Next | Last >>
Jump to: