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Found 415 with Last Name = 'hiestand' and Initial = 'p'
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174708(CHEMBL197375 | N-(2-(3-((2R,5S)-4-(4-fluorobenzyl)...)
Affinity DataIC50:  0.100nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174703((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  0.400nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175995(CHEMBL199986 | N-(2,4-difluorophenyl)-3-(5-(3-(dim...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176013(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-b]p...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174707((R)-1-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  0.900nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176003(CHEMBL199993 | N-(2,4-difluorophenyl)-3-(2-methoxy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348545(CHEMBL1801384)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174711(CHEMBL197345 | N-(2-(3-((2S,5R)-4-(4-fluorobenzyl)...)
Affinity DataIC50:  1nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174709(CHEMBL372807 | N-(2-(3-(3-(4-fluorobenzyl)-3,8-dia...)
Affinity DataIC50:  1nMAssay Description:Antagonistic activity at rat CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348537(CHEMBL1801376)
Affinity DataIC50:  1nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148700(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  2nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348534(CHEMBL1801373)
Affinity DataIC50:  2nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174720((R)-N-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  2.40nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174703((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263609(2-cyano-4-((1-(2-hydroxyethyl)piperidin-4-yl)metho...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263557(2-cyano-4-((1-isopropylpiperidin-4-yl)methoxy)-N-m...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263555(2-cyano-N-methyl-4-((1-methylpiperidin-4-yl)methox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148699(4-{2-(4-Fluoro-phenyl)-1-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  4nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  4nMAssay Description:Antagonistic activity at human CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116037(3,5-Difluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263554(2-cyano-N-methyl-4-(2-(1-methylpiperidin-4-yl)etho...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116031(3,5,6-Trifluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148703(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174709(CHEMBL372807 | N-(2-(3-(3-(4-fluorobenzyl)-3,8-dia...)
Affinity DataIC50:  4nMAssay Description:Antagonistic activity at mouse CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148691(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148702(CHEMBL415712 | Cyclohexyl-{4-[2-(4-fluoro-phenyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175994(CHEMBL371756 | N-cyclopentyl-3-(6-(2,4-difluorophe...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348542(CHEMBL1801381)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348546(CHEMBL1801385)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348543(CHEMBL1801382)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263610(2-cyano-N-methyl-4-(piperidin-4-ylmethoxy)-6-(spir...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116038(4-(4-Benzofuran-2-yl-5-pyridin-4-yl-1H-imidazol-2-...)
Affinity DataIC50:  5nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263611(2-cyano-N-methyl-4-(spiro[3.5]nonan-7-ylmethylamin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148696(CHEMBL119952 | {4-[(S)-2-(4-Fluoro-phenyl)-5-(4-me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263667(2-cyano-4-(2-hydroxyethoxy)-N-methyl-6-(spiro[3.5]...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174718(CHEMBL200680 | N-(6-(3-(3-(4-fluorobenzyl)-3,8-dia...)
Affinity DataIC50:  6nMAssay Description:Antagonistic activity at rat CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174709(CHEMBL372807 | N-(2-(3-(3-(4-fluorobenzyl)-3,8-dia...)
Affinity DataIC50:  7nMAssay Description:Antagonistic activity at human CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175998(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148693(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  7nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174709(CHEMBL372807 | N-(2-(3-(3-(4-fluorobenzyl)-3,8-dia...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148698(CHEMBL333899 | Cyclohexyl-{4-[4-piperidin-4-yl-2-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348535(CHEMBL1801374)
Affinity DataIC50:  8nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148695(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  9nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174710(CHEMBL200242 | N-(2-(3-(3-(4-fluorobenzyl)-3,8-dia...)
Affinity DataIC50:  9nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174708(CHEMBL197375 | N-(2-(3-((2R,5S)-4-(4-fluorobenzyl)...)
Affinity DataIC50:  9nMAssay Description:Antagonistic activity at human CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174704((R)-N-(2-(1-(4-fluorobenzyl)-3-methylpiperazine-4-...)
Affinity DataIC50:  9.60nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50348524(CHEMBL1801388)
Affinity DataIC50:  10nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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