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Found 140 with Last Name = 'qiu' and Initial = 'r'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50277608(CHEMBL4173067)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to human FLT3 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50277608(CHEMBL4173067)
Affinity DataKi:  110nMAssay Description:Binding affinity MNK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) phosphorylation in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM13535(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FLT3 D835H mutant (unknown origin) phosphorylation in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))TBA
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50422751(DENFIVONTINIB | Denfivontinib | G-749)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FLT3 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50422749(CHEMBL5287891)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50422752(CHEMBL5284731)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of FLT3-ITD mutant phosphorylation in human MOLM-14 cell incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50380950(CHEMBL2016905)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337332(2-(4-chlorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50422751(DENFIVONTINIB | Denfivontinib | G-749)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337333(2-(4-fluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337334(2-(4-chloro-2,6-difluorophenyl)-1-(4-(4-(5-methyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337335((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50601438(CHEMBL5170277)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibitionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337336(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337337(2-(4-methoxyphenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337338(2-(2,6-difluoro-4-methoxyphenyl)-1-(4-(4-(5-methyl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human SEMK2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337339(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337340((2-bromophenyl)(4-(4-(5-methyl-1H-pyrazol-3-ylamin...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337341((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337342(2-(2,6-difluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazo...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50380974(CHEMBL2016903)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337343(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM350864(UNC1666A | US10004755, Compound UNC1666A | US97956...)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337344((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337345((2-methoxyphenyl)(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337346((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50422748(CHEMBL5269280)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337347(2-(2-fluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337348(4-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human SEMK2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337349(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50422745(CHEMBL4066041)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337350(2-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50422748(CHEMBL5269280)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50337351((2-chlorophenyl)(4-(4-(5-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of JAK2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50250180(CHEMBL4101411)
Affinity DataIC50:  9nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
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