Affinity DataKi: 1.74nMAssay Description:Inhibition of rabbit factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 2.85nMAssay Description:Inhibition of human factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 8.77nMAssay Description:Inhibition of rat factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 2.54E+3nMAssay Description:Inhibition of human thrombin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+4nMAssay Description:Inhibition of human recombinant tissue plasminogen activator by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 2.30E+4nMAssay Description:Inhibition of human plasmin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 6.82E+4nMAssay Description:Inhibition of human recombinant tissue plasminogen activator by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant factor 7a/soluble tissue factor by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human plasmin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of human thrombin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyoto 619-0216
Curated by ChEMBL
Kyoto 619-0216
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery
Curated by ChEMBL
Kirin Brewery
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyoto 619-0216
Curated by ChEMBL
Kyoto 619-0216
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta)More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair