Affinity DataKi: 0.220nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Inhibition of recombinant human 11beta-HSD1 expressed in HEK293 cell microsomes using [3H]cortisone as substrate after 4 hrs by homogeneous immuno-ra...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Agonist activity at dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Agonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Antagonist activity at rat adenosine A1 receptorMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Inhibition of human 11beta-HSD-1More data for this Ligand-Target Pair
Affinity DataKi: 9.5nMAssay Description:Antagonist activity at rat adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at rat adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 121nMAssay Description:Antagonist activity at adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >250nMAssay Description:Antagonist activity at rat adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 255nMAssay Description:Antagonist activity at human adenosine A1 receptorMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataKi: 370nMAssay Description:Binding affinity to human KDM1A (172 to 833 residues) assessed as inhibition constant using Lys4-dimethylated H3 peptide as substrate incubated for 3...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 380nMAssay Description:Inhibition of recombinant mouse 11beta-HSD1 expressed in HEK293 cell microsomes using [3H]cortisone as substrate after 4 hrs by homogeneous immuno-ra...More data for this Ligand-Target Pair
Affinity DataKi: >540nMAssay Description:Antagonist activity at human adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 820nMAssay Description:Antagonist activity at human adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Antagonist activity at human adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nMAssay Description:Antagonist activity at human adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.23E+3nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataKi: 7.11E+3nMAssay Description:Binding affinity to KDM6B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataKi: 7.46E+3nMAssay Description:Binding affinity to KDM6B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Antagonist activity at human adenosine A1 receptorMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 2(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataKi: >2.50E+5nMAssay Description:Binding affinity to KDM1B (unknown origin) assessed as inhibition constant using Lys4-dimethylated H3 peptide as substrate incubated for 30 mins by e...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataKi: >2.50E+5nMAssay Description:Binding affinity to human MAO-A assessed as inhibition constant using tyramine as substrate incubated for 30 mins by enzymatic assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataKi: >2.50E+5nMAssay Description:Binding affinity to human MAO-B assessed as inhibition constant using tyramine as substrate incubated for 30 mins by enzymatic assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human 11beta-HSD1 expressed in HEK293 cell microsomes using [3H]cortisone as substrate after 4 hrs by homogeneous immuno-ra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of mouse STC1 in cell based assayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human STC1 in cell based assayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]PIA from adenosine A1 receptor of rat brain membranesMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Hangzhou Normal University
Curated by ChEMBL
Hangzhou Normal University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human KDM1A (172 to 852 residues) using Bio-H3K4me2 peptide as substrate incubated for 1 hr by Lance ultra assayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human 11beta-HSD-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins ...More data for this Ligand-Target Pair