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Found 810 with Last Name = 'yao' and Initial = 'z'
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  3.96nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50048891((3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-...)
Affinity DataKi:  4.47nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50017701(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Affinity DataKi:  7.62nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342820((2S,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  13.4nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342822((2R,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  71.1nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342824((2S,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  593nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342825((2R,3R,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  1.25E+3nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342821((2R,3S,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  2.46E+3nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342823((2S,3R,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  4.63E+3nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342819((2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,1...)
Affinity DataKi:  2.37E+4nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50131098(2-(4-{2-((S)-1-(S)-Carbamoyl-3-methyl-butylcarbamo...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibitory potency against human Protein-tyrosine phosphatase 1B expressed in E. coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50342818((3S,11BS)-TETRABENAZINE | CHEMBL519344)
Affinity DataKi:  3.64E+4nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50578549(CHEMBL4876454)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50228403((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046798(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  0.240nMpH: 7.4Assay Description:In vitro inhibitory concentration against monkey plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464633(CHEMBL4285830 | US11091476, Example 13)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50578549(CHEMBL4876454)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM119782(US8691832, 1)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464632(CHEMBL4279832 | US11091476, Example 30)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046799(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  0.720nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046794(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  0.760nMpH: 7.4Assay Description:In vitro inhibitory concentration against monkey plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046802(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  0.800nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046796((S)-N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-di...)
Affinity DataIC50:  0.870nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464630(CHEMBL4281514 | US11091476, Example 18)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM50243294(CHEMBL4094513)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PRMT8 (unknown origin) incubated for 15 mins followed by substrate addition measured after 60 mins by AlphaLisa methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Rattus norvegicus)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM50243294(CHEMBL4094513)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of rat His-tagged PRMT1 (11 to 353 residues) expressed in Escherichia coli BL21(DE3) incubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046798(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:In vitro inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046798(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:In vitro inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM50243294(CHEMBL4094513)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PRMT6 (unknown origin) incubated for 15 mins followed by substrate addition measured after 60 mins by AlphaLisa methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM119786(US8691832, 5)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50011228((R)-2-Benzyl-N-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046801(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046808(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  1.60nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046806(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  1.60nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022647(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.60nMpH: 7.4Assay Description:Inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM119788(US8691832, 7)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM60417(US9051329, Example 1)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50580530(CHEMBL5092744)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human PD-1/PD-L1 interaction assessed as blockade activity incubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046805(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.80nMpH: 7.4Assay Description:Inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464615(CHEMBL4289350 | US11091476, Example 3)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50085869(CHEMBL367037 | N-[1-(1-{2-Carbamoyl-1-[3-(5-methyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50578544(CHEMBL4866683)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-LeuGlyLy-s(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and further inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50580548(CHEMBL5081629)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human PD-1/PD-L1 interaction assessed as blockade activity incubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046794(2-Benzyl-N*1*-[1-(1-cyclohexylmethyl-2,3-dihydroxy...)
Affinity DataIC50:  2.60nMpH: 7.4Assay Description:In vitro inhibitory concentration against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50046785(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  2.80nMpH: 7.4Assay Description:Inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/Cyclin-D1 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Wigen Biomedicine Technology (Shanghai)

US Patent
LigandPNGBDBM500022(US11021457, Compound 26)
Affinity DataIC50: <3nMAssay Description:By constructing a prokaryotic expression system, the LC3B protein was successfully expressed and purified, and a preliminary screening and verificati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Wigen Biomedicine Technology (Shanghai)

US Patent
LigandPNGBDBM500145(US11021457, Compound 157)
Affinity DataIC50: <3nMAssay Description:By constructing a prokaryotic expression system, the LC3B protein was successfully expressed and purified, and a preliminary screening and verificati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Wigen Biomedicine Technology (Shanghai)

US Patent
LigandPNGBDBM500144(US11021457, Compound 156)
Affinity DataIC50: <3nMAssay Description:By constructing a prokaryotic expression system, the LC3B protein was successfully expressed and purified, and a preliminary screening and verificati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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