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Found 697 with Last Name = 'aerts' and Initial = 'jm'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM162702(US9056847, Fluorophore 1-cyclophellitol)
Affinity DataKi:  0.950nM IC50:  2nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM60418(US9056847, Fluorophore 2-cyclophellitol)
Affinity DataKi:  1.56nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36514(CID46912122 | MDW933, 5)
Affinity DataKi:  7nM ΔG°:  -48.4kJ/mole IC50:  1.24nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36515(CID46912120 | MDW941, 6)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/mole IC50:  1.94nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitinase B(Serratia marcescens)
University of Dundee

LigandPNGBDBM10854(4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethan...)
Affinity DataKi:  20nM ΔG°:  -45.7kJ/molepH: 5.5 T: 2°CAssay Description:The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36513(CID46912128 | KY170, 4 | US9056847, Azido-cyclophe...)
Affinity DataKi:  44nM ΔG°:  -43.7kJ/mole IC50:  120nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36513(CID46912128 | KY170, 4 | US9056847, Azido-cyclophe...)
Affinity DataKi:  83nM IC50:  150nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36512(CID164227 | Cylcophellitol, 3 | US11826435, Compou...)
Affinity DataKi:  152nM ΔG°:  -40.5kJ/mole IC50:  150nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  7.73E+3nM IC50:  1.20E+4nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitinase B(Serratia marcescens)
University of Dundee

LigandPNGBDBM10853((2R,5S,8S,11S,15S)-8-benzyl-2,7-dimethyl-5-[3-({[(...)
Affinity DataKi:  3.30E+4nM ΔG°:  -26.6kJ/molepH: 5.5 T: 2°CAssay Description:The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  5.30E+4nM ΔG°:  -25.4kJ/mole IC50:  9.49E+3nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028180(CHEMBL3354625)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028179(CHEMBL3354624)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028244(CHEMBL3354627)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028254(CHEMBL3354634)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028255(CHEMBL3354635)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028181(CHEMBL3354626)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028256(CHEMBL3354636)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028221(CHEMBL3354041)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028257(CHEMBL3354637)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028249(CHEMBL3354629)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028217(CHEMBL3354037)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028176(CHEMBL3354621)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312527(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Affinity DataIC50: <1nMAssay Description:Inhibition of GBA2 by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312529(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Affinity DataIC50: <1nMAssay Description:Inhibition of GBA2 by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028229(CHEMBL3354048)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028230(CHEMBL3354049)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  1nMAssay Description:Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312527(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028188(CHEMBL3354019)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028203(CHEMBL3354021)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028204(CHEMBL3354022)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028215(CHEMBL3354035)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312529(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028173(CHEMBL3354063)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028248(CHEMBL3354628)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028207(CHEMBL3354025)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028251(CHEMBL3354631)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028252(CHEMBL3354632)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028253(CHEMBL3354633)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028258(CHEMBL3354638)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028214(CHEMBL3354032)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028226(CHEMBL3354046)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028231(CHEMBL3354050)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028232(CHEMBL3354051)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028235(CHEMBL3354054)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028220(CHEMBL3354040)
Affinity DataIC50:  2nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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