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Found 170 with Last Name = 'alexander' and Initial = 'jp'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021345(CHEMBL3287928)
Affinity DataKi:  637nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021331(CHEMBL3287930)
Affinity DataKi:  740nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350538(CHEMBL1812717)
Affinity DataKi:  1.25E+3nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021346(CHEMBL3287926)
Affinity DataKi:  1.54E+3nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021329(CHEMBL3287932)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021344(CHEMBL3287929)
Affinity DataKi:  5.21E+3nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021334(CHEMBL3287931)
Affinity DataKi:  2.85E+4nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021330(CHEMBL3287927)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM26736(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Affinity DataIC50:  0.0900nMpH: 7.4 T: 2°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503336(CHEMBL4437377)
Affinity DataIC50:  2nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503331(CHEMBL4522687)
Affinity DataIC50:  2nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503340(CHEMBL4468636)
Affinity DataIC50:  2nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180052(US9133148, 9aq)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MGLL in human intact PC3 cells preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM179948(US9133148, 2l)
Affinity DataIC50:  3nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180039(US9133148, 9ad)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503335(CHEMBL4450649)
Affinity DataIC50:  4nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503334(CHEMBL4468639)
Affinity DataIC50:  4nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021344(CHEMBL3287929)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180078(US9133148, 10g)
Affinity DataIC50:  5nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM26736(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Affinity DataIC50:  5.30nMpH: 7.4 T: 2°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503339(CHEMBL4469632)
Affinity DataIC50:  6nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021345(CHEMBL3287928)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021334(CHEMBL3287931)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021330(CHEMBL3287927)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50503336(CHEMBL4437377)
Affinity DataIC50:  8nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutral cholesterol ester hydrolase 1(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM26736(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Affinity DataIC50:  8.20nMpH: 7.4 T: 2°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503333(CHEMBL4539731)
Affinity DataIC50:  9nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021331(CHEMBL3287930)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350538(CHEMBL1812717)
Affinity DataIC50:  11nMAssay Description:Inhibition of human FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503342(CHEMBL4436074)
Affinity DataIC50:  11nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350538(CHEMBL1812717)
Affinity DataIC50:  11nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503327(CHEMBL4435014)
Affinity DataIC50:  11nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM179938(US9133148, 2b)
Affinity DataIC50:  12nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503344(CHEMBL4439400)
Affinity DataIC50:  12nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM26736(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Mouse brain membrane proteomes were preincubated with varying concentrations of inhibitors for 10 min prior to the addition of a rhodamine-tagged flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021334(CHEMBL3287931)
Affinity DataIC50:  13nMAssay Description:Inhibition of human FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021344(CHEMBL3287929)
Affinity DataIC50:  13nMAssay Description:Inhibition of human FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180052(US9133148, 9aq)
Affinity DataIC50:  14nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50503333(CHEMBL4539731)
Affinity DataIC50:  14nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50503331(CHEMBL4522687)
Affinity DataIC50:  15nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503337(CHEMBL4517565)
Affinity DataIC50:  15nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021345(CHEMBL3287928)
Affinity DataIC50:  16nMAssay Description:Inhibition of human FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  16.2nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180033(US9133148, 9x)
Affinity DataIC50:  17nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM50503345(CHEMBL4550205)
Affinity DataIC50:  17nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50503340(CHEMBL4468636)
Affinity DataIC50:  17nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50503334(CHEMBL4468639)
Affinity DataIC50:  17nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180029(US9133148, 9t)
Affinity DataIC50:  18nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180076(US9133148, 10e)
Affinity DataIC50:  20nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50021329(CHEMBL3287932)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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