Affinity DataKi: 0.100nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: 1.18nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 42nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 69.9nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 98nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 159nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 183nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 184nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 198nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 214nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 296nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 311nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 322nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 331nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 398nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 418nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 481nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 565nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 614nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 767nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.62E+3nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.68E+3nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6.37E+3nMAssay Description:Binding affinity to human B1 bradykinin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6.37E+3nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human B1 receptorMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair