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Found 493 with Last Name = 'aluisio' and Initial = 'l'
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50089369(CHEMBL3577959)
Affinity DataKi:  0.700nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206229(3-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216249((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206218(6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206222(6-phenyl-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,1...)
Affinity DataKi:  0.900nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.970nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50089374(CHEMBL3577954)
Affinity DataKi:  1nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216252((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216251((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50089375(CHEMBL3577953)
Affinity DataKi:  1nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50321465((6-(3-chlorophenoxy)pyridin-3-yl)(4-cyclobutyl-1,4...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317720((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206235(4-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216252((6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206228(6-(3-chlorophenyl)-9-(3-(piperidin-1-yl)propoxy)-1...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHrh3 protein(RAT)
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  1.26nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50089372(CHEMBL3577956)
Affinity DataKi:  1.30nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50346208((1-isopropylpiperidin-4-yl)(4-(piperidin-1-ylmethy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50206229(3-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317711(((2R,4S)-4-(4-chloro-3-methylphenoxy)pyrrolidin-2-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206225(6-(4-nitrophenyl)-9-(3-(piperidin-1-yl)propoxy)-1,...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206227(6-(2-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50321503((5-(3,4-dichlorophenoxy)pyridin-2-yl)(4-isopropyl-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317706(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50089370(CHEMBL3577958)
Affinity DataKi:  1.5nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317698(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216248((6R,10bR)-9-(3-morpholinopropoxy)-6-(pyridin-3-yl)...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206233(CHEMBL238951 | N,N-dimethyl-4-(9-(3-(piperidin-1-y...)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206217(4-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206221(6-(3-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206236(6-(4-fluorophenyl)-9-(3-(piperidin-1-yl)propoxy)-1...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317716((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50321466(3-(5-(4-cyclobutyl-1,4-diazepane-1-carbonyl)pyridi...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216245((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50206222(6-phenyl-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,1...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50216256((6S,10bR)-6-(H-imidazo[1,2-a]pyridin-3-yl)-9-(3-mo...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206232(6-(3-ethynylphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50089368(CHEMBL3577960)
Affinity DataKi:  2nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216242((6R,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-3-yl...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206219(9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethy...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50206224(9-(3-(piperidin-1-yl)propoxy)-6-p-tolyl-1,2,3,5,6,...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317701(((2R,4S)-4-(4-chlorophenoxy)pyrrolidin-2-yl)(4-cyc...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by PDSP Ki Database
LigandPNGBDBM50317728(1-((2R,4S)-2-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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