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Found 97 with Last Name = 'aoyama' and Initial = 'h'
TargetProthrombin(Bos taurus (Bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322033(2-Methylisoindole-1,3-dione-5-yl 3-(6-aminopyridin...)
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322034(2-(4-Cyanophenyl)isoindole-1,3-dione-5-yl(E)-3-(4-...)
Affinity DataKi:  8.60E+3nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322032(2-Methylisoindole-1,3-dione-5-yl 3-(4-aminophenyl)...)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322035(2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-ami...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50368147((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539575(CHEMBL4643381)
Affinity DataIC50:  34nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50011036((S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxo-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539573(CHEMBL4636043)
Affinity DataIC50:  46nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539577(CHEMBL4633378)
Affinity DataIC50:  47nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539578(CHEMBL4641865)
Affinity DataIC50:  90nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539576(CHEMBL4639168)
Affinity DataIC50:  108nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296079(CHEMBL562679 | sodium(3R,5S,E)-7-(4'-fluoro-5-(3-p...)
Affinity DataIC50:  150nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50322033(2-Methylisoindole-1,3-dione-5-yl 3-(6-aminopyridin...)
Affinity DataIC50:  190nMAssay Description:Inhibition of tryptase (unknown origin) using t-Boc-Phe-Ser-Arg-MCA as substrate after 5 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539572(CHEMBL4640750)
Affinity DataIC50:  201nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539574(CHEMBL4632477)
Affinity DataIC50:  290nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251287(CHEMBL457292 | N-[(R)-3-Hydroxycarbamoyl-2-pentylp...)
Affinity DataIC50:  530nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251279((S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbu...)
Affinity DataIC50:  690nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251279((S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbu...)
Affinity DataIC50:  690nMAssay Description:Degradation promoting activity of FLAG tagged cIAP1(unknown origin) expressed in human HT1080 cells after 3 hrs by western blotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296077(CHEMBL560523 | sodium(3R,5S,E)-7-(2'-fluoro-5-(3-p...)
Affinity DataIC50:  820nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251296(CHEMBL458592 | N-[(R)-3-Hydroxycarbamoyl-2-pentylp...)
Affinity DataIC50:  840nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296076(CHEMBL560325 | sodium(3R,5S,E)-3,5-dihydroxy-7-(5-...)
Affinity DataIC50:  850nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251280(CHEMBL457093 | N-[(R)-3-Hydroxycarbamoyl-2-pentylp...)
Affinity DataIC50:  1.06E+3nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50322033(2-Methylisoindole-1,3-dione-5-yl 3-(6-aminopyridin...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-Arg-pNA.HCl as substrate after 5 mins by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296078(CHEMBL557852 | sodium(3R,5S,E)-7-(3'-fluoro-5-(3-p...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251288(CHEMBL457293 | N-[(R)-3-Hydroxycarbamoyl-2-pentylp...)
Affinity DataIC50:  1.25E+3nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396607(CHEMBL2171827)
Affinity DataIC50:  1.30E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251286(CHEMBL457060 | N-[(R)-3-Hydroxycarbamoyl-2-pentylp...)
Affinity DataIC50:  1.54E+3nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396590(CHEMBL2171915)
Affinity DataIC50:  1.70E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296080(CHEMBL551868 | sodium(3R,5S,E)-3,5-dihydroxy-7-(2-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50260679((S)-2-(1-(dimethylamino)naphthalene-5-sulfonamido)...)
Affinity DataIC50:  1.86E+3nMAssay Description:Degradation promoting activity of FLAG tagged cIAP1(unknown origin) expressed in human HT1080 cells after 3 hrs by western blotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50260680((S)-2-(1-azidonaphthalene-5-sulfonamido)ethyl 2-((...)
Affinity DataIC50:  1.89E+3nMAssay Description:Degradation promoting activity of FLAG tagged cIAP1(unknown origin) expressed in human HT1080 cells after 3 hrs by western blotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396605(CHEMBL2171829)
Affinity DataIC50:  2.20E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296073(CHEMBL562883 | sodium(3R,5S,E)-7-(4-(3-(4-fluoroph...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396601(CHEMBL2171902)
Affinity DataIC50:  4.10E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396595(CHEMBL2171906)
Affinity DataIC50:  4.10E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50539575(CHEMBL4643381)
Affinity DataIC50:  4.47E+3nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251297(CHEMBL458594 | N-[(R)-3-Hydroxycarbamoyl-2-butylam...)
Affinity DataIC50:  4.69E+3nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396604(CHEMBL2171905)
Affinity DataIC50:  4.90E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50322033(2-Methylisoindole-1,3-dione-5-yl 3-(6-aminopyridin...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of thrombin (unknown origin) using t-Boc-Val-Pro-Arg-MCA as substrate after 5 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396589(CHEMBL2171916)
Affinity DataIC50:  5.40E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396603(CHEMBL2171901)
Affinity DataIC50:  6.10E+3nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50296075(CHEMBL564931 | sodium(3R,5S,E)-7-(4-(3-(2-fluoroph...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396604(CHEMBL2171905)
Affinity DataIC50:  7.50E+3nMAssay Description:Transactivational antagonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251298(CHEMBL458777 | N-[(R)-3-Hydroxycarbamoyl-2-dibutyl...)
Affinity DataIC50:  9.20E+3nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396607(CHEMBL2171827)
Affinity DataIC50:  9.50E+3nMAssay Description:Transactivational antagonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396588(CHEMBL2171910)
Affinity DataIC50: >1.00E+4nMAssay Description:Transactivational antagonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396600(CHEMBL2171903)
Affinity DataIC50: >1.00E+4nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396588(CHEMBL2171910)
Affinity DataIC50: >1.00E+4nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396594(CHEMBL2171911)
Affinity DataIC50: >1.00E+4nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50396592(CHEMBL2171913)
Affinity DataIC50: >1.00E+4nMAssay Description:Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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