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Found 632 with Last Name = 'arnold' and Initial = 'la'
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of alpha1A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529212(CHEMBL4471453)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein polybromo-1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529212(CHEMBL4471453)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of PBR receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529213(CHEMBL4465132)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of D3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529213(CHEMBL4465132)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of HDAC3 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC1 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of trypsin-induced intracellular calcium mobilization preincubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of HDAC2 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC8 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503928(CHEMBL4459024)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKaposi's sarcoma-associated herpesvirus cyclin homolog(Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-...)
University of California San Francisco

LigandPNGBDBM36461(3-Benzyl-4-(3-(cyclohexylmethyl)-4-methoxybenzamid...)
Affinity DataIC50:  16.4nMpH: 8.0 T: 2°CAssay Description:Human herpesvirus assay using human Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503926(CHEMBL4472608)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503924(CHEMBL4437508)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataIC50:  48nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529215(CHEBI:35046 | CHEMBL342375)
Affinity DataIC50:  55nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503928(CHEMBL4459024)
Affinity DataIC50:  97nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503929(CHEMBL4578092)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503925(CHEMBL4540591)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529213(CHEMBL4465132)
Affinity DataIC50:  160nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503925(CHEMBL4540591)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  180nMAssay Description:Inhibition of HDAC6 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529212(CHEMBL4471453)
Affinity DataIC50:  200nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512562(CHEMBL4438936)
Affinity DataIC50:  200nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512562(CHEMBL4438936)
Affinity DataIC50:  220nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512565(CHEMBL4451525)
Affinity DataIC50:  316nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512565(CHEMBL4451525)
Affinity DataIC50:  320nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503925(CHEMBL4540591)
Affinity DataIC50:  360nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of thrombin-induced intracellular calcium mobilization preincubated for 15 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512563(CHEMBL4514779)
Affinity DataIC50:  370nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512563(CHEMBL4514779)
Affinity DataIC50:  370nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512561(CHEMBL4448258)
Affinity DataIC50:  380nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512561(CHEMBL4448258)
Affinity DataIC50:  398nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512564(CHEMBL4594058)
Affinity DataIC50:  398nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294961(1-(2-Chloro-4-(hexylsulfonyl)phenyl)-3-(4-(ethylsu...)
Affinity DataIC50:  400nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50512564(CHEMBL4594058)
Affinity DataIC50:  420nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Affinity DataIC50:  480nMAssay Description:Antagonist activity at PAR2 in human MDA-MB-231 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294962(3-(4-Acetylpiperazin-1-yl)-1-(2-chloro-4-(hexylsul...)
Affinity DataIC50:  500nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529217(CHEMBL4447214)
Affinity DataIC50:  540nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50446373(CHEMBL3109624)
Affinity DataIC50:  590nMAssay Description:Inhibition of 1,25(OH)2D3-induced VDR (unknown origin)-mediated CYP24A1 transcription expressed in HEK293T cells after 16 hrs by luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50446350(CHEMBL3109604)
Affinity DataIC50:  590nMAssay Description:Inhibition of 1,25(OH)2D3-induced VDR (unknown origin)-mediated CYP24A1 transcription expressed in HEK293T cells after 16 hrs by luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294969(4-(3-(2,5-Dichloro-4-(hexylsulfonyl)phenyl)-3-oxop...)
Affinity DataIC50:  600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294964(3-(4-Acetylpiperazin-1-yl)-1-(2,3-dichloro-4-(hexy...)
Affinity DataIC50:  600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294967(4-(3-(2,5-Dichloro-4-(hexylthio)phenyl)-3-oxopropy...)
Affinity DataIC50:  600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294966(3-(4-Acetylpiperazin-1-yl)-1-(2-chloro-4-(hexylthi...)
Affinity DataIC50:  600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294965(3-(4-acetylpiperazin-1-yl)-1-(2,6-dichloro-4-(hexy...)
Affinity DataIC50:  600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital

Curated by ChEMBL
LigandPNGBDBM50294968(1-(2-Chloro-4-(hexylsulfonyl)phenyl)-3-morpholinop...)
Affinity DataIC50:  600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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