Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of alpha1A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.50E+3nMAssay Description:Inhibition of PBR receptor (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataKi: 3.90E+3nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of D3 receptor (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC3 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC1 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of trypsin-induced intracellular calcium mobilization preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of HDAC2 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
TargetKaposi's sarcoma-associated herpesvirus cyclin homolog(Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-...)
University of California San Francisco
University of California San Francisco
Affinity DataIC50: 16.4nMpH: 8.0 T: 2°CAssay Description:Human herpesvirus assay using human Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr).More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of HDAC6 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 316nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of thrombin-induced intracellular calcium mobilization preincubated for 15 ...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Antagonist activity at PAR2 in human MDA-MB-231 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University
Curated by ChEMBL
Marquette University
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of 1,25(OH)2D3-induced VDR (unknown origin)-mediated CYP24A1 transcription expressed in HEK293T cells after 16 hrs by luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of 1,25(OH)2D3-induced VDR (unknown origin)-mediated CYP24A1 transcription expressed in HEK293T cells after 16 hrs by luciferase reporter ...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
St. Jude Children'S Hospital
Curated by ChEMBL
St. Jude Children'S Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair