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Found 233 with Last Name = 'asahi' and Initial = 's'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173629(CHEMBL197912 | Cyclopentyl-[4-(2-ethyl-4-m-tolyl-t...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173614(CHEMBL196575 | [4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)...)
Affinity DataIC50:  5.10nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358192(CHEMBL1921975)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173627(CHEMBL197581 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Affinity DataIC50:  5.60nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338363(CHEMBL1682893 | rac-6-[1-Hydroxy-1-(1H-imidazol-4-...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173621(Benzyl-[4-(2-ethyl-4-m-tolyl-thiazol-5-yl)-pyridin...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(CHEMBL363648 | D3RKN_11 | N-[4-(2-Ethyl-4-m-tolyl-...)
Affinity DataIC50:  7.10nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
LigandPNGBDBM50109937((R)-2-[(Indane-2-carbonyl)-amino]-3-naphthalen-1-y...)
Affinity DataIC50:  7.30nMAssay Description:Tested for the inhibition of Candida GGTase I in Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173606(CHEMBL198383 | Cyclohexanecarboxylic acid [4-(2-et...)
Affinity DataIC50:  7.90nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173617(CHEMBL381864 | [4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)...)
Affinity DataIC50:  8.10nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173633(CHEMBL194201 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Affinity DataIC50:  8.10nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173622(CHEMBL199160 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Affinity DataIC50:  8.80nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405453(CHEMBL5271309)
Affinity DataIC50:  8.90nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173626(CHEMBL382103 | {4-[2-(4-Methanesulfonyl-phenyl)-4-...)
Affinity DataIC50:  9.10nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109938(9H-Xanthene-9-carboxylic acid {(R)-2-(3,4-dichloro...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Candida geranylgeranyl transferase I at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173611(Benzyl-{4-[2-(4-methanesulfonyl-phenyl)-4-m-tolyl-...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173623(CHEMBL383569 | N-[4-(2-Methyl-4-m-tolyl-thiazol-5-...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173607(CHEMBL197545 | N-[4-(2-Propyl-4-m-tolyl-thiazol-5-...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173638(CHEMBL197772 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358195(CHEMBL1921979)
Affinity DataIC50:  13nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173630(4-[2-(4-Methanesulfonyl-phenyl)-4-m-tolyl-thiazol-...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358195(CHEMBL1921979)
Affinity DataIC50:  15nMAssay Description:Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173628(4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridine | CHEM...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338363(CHEMBL1682893 | rac-6-[1-Hydroxy-1-(1H-imidazol-4-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109933(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)
Affinity DataIC50:  17nMAssay Description:Tested for the inhibition of Candida GGTase I in Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109933(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)
Affinity DataIC50:  17nMAssay Description:Tested for the inhibition of Candida GGTase I in Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405449(CHEMBL5266711)
Affinity DataIC50:  18nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  18nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  18nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  18nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405450(CHEMBL5315609)
Affinity DataIC50:  18nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358201(CHEMBL1921976 | US9611270, orteronel)
Affinity DataIC50:  19nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173612(4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-ylami...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405449(CHEMBL5266711)
Affinity DataIC50:  22nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358197(CHEMBL1921981)
Affinity DataIC50:  24nMAssay Description:Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173608(CHEMBL371920 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173616(4-[2-(4-Methanesulfonyl-phenyl)-4-m-tolyl-thiazol-...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358197(CHEMBL1921981)
Affinity DataIC50:  29nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173637(CHEMBL194595 | N-{4-[4-(3-Chloro-phenyl)-2-ethyl-t...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173618(CHEMBL371188 | N-[4-(2-Ethyl-4-phenyl-thiazol-5-yl...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173619(CHEMBL425909 | N-{4-[2-Ethyl-4-(4-fluoro-phenyl)-t...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109940(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)
Affinity DataIC50:  31nMAssay Description:Tested for the inhibition of Candida GGTase I in Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173632(CHEMBL197799 | N-{4-[2-(4-Methanesulfonyl-phenyl)-...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173613(CHEMBL371716 | N-{4-[2-(4-Methanesulfonyl-phenyl)-...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358193(CHEMBL1921977)
Affinity DataIC50:  38nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
LigandPNGBDBM50405450(CHEMBL5315609)
Affinity DataIC50:  43nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358202(CHEMBL1921985)
Affinity DataIC50:  48nMAssay Description:Inhibition of 17,20-lyase activity of human CYP17A1More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358201(CHEMBL1921976 | US9611270, orteronel)
Affinity DataIC50:  48nMAssay Description:Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173636(4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-2-methyl-pyridi...)
Affinity DataIC50:  53nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358193(CHEMBL1921977)
Affinity DataIC50:  54nMAssay Description:Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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