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Found 153 with Last Name = 'ashe' and Initial = 'bm'
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015931(3-Benzenesulfonylmethyl-7-methoxy-5,5,8-trioxo-5la...)
Affinity DataKi:  220nMAssay Description:In vitro inhibitory activity against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003164(1-[3-(6-Hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]...)
Affinity DataKi:  250nMAssay Description:In vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003161(3-Ethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-a...)
Affinity DataKi:  500nMAssay Description:Second order rate constant for the in vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281051((2S,5R,6S)-6-Ethoxy-3,3-dimethyl-4,4,7-trioxo-4lam...)
Affinity DataKi:  1.30E+3nMAssay Description:Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281052((2S,5R,6S)-3,3-Dimethyl-4,7-dioxo-6-(2,2,2-trifluo...)
Affinity DataKi:  1.50E+3nMAssay Description:Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015926(7-Methoxy-3-methoxymethyl-5,5,8-trioxo-5lambda*6*-...)
Affinity DataKi:  1.60E+3nMAssay Description:In vitro inhibitory activity against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50368407(CHEMBL446371 | L-658758)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibitory activity agaiinst HLE at 10 min (48 mM conc)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50406689(CHEMBL2114137)
Affinity DataKi:  3.40E+3nMAssay Description:In vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003160(CHEMBL435611 | [(3-Acetoxymethyl-7-methoxy-5,5,8-t...)
Affinity DataKi:  6.10E+3nMAssay Description:In vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281055(CHEMBL73926 | {[(2S,5R,6S)-3,3-Dimethyl-4,4,7-trio...)
Affinity DataKi:  1.40E+4nMAssay Description:Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280495(4-((2S,3S)-3-Ethyl-1-methylcarbamoyl-4-oxo-azetidi...)
Affinity DataKi:  1.65E+4nMAssay Description:Concentration required for inhibition of human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281054((R)-1-[(2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-(2,2...)
Affinity DataKi:  2.20E+4nMAssay Description:Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016904(CHEMBL3273012)
Affinity DataKi:  2.20E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016905(CHEMBL3273010)
Affinity DataKi:  3.60E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016903(CHEMBL3273013)
Affinity DataKi:  3.80E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016929(CHEMBL3273011)
Affinity DataKi:  3.90E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016906(CHEMBL3273009)
Affinity DataKi:  3.90E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016930(CHEMBL3273008)
Affinity DataKi:  3.90E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003162(CHEMBL123475 | {[7-Methoxy-5,5,8-trioxo-3-(pyridin...)
Affinity DataKi:  4.30E+4nMAssay Description:In vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281056(CHEMBL307622 | {[(2S,5R,6R)-3,3-Dimethyl-4,4,7-tri...)
Affinity DataKi:  5.00E+4nMAssay Description:Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031664(4-((2R,3R)-1-Benzylcarbamoyl-3-methyl-4-oxo-3-prop...)
Affinity DataKi:  5.10E+4nMAssay Description:Compound was evaluated in vitro for the human leukocyte elastase (HLE) inhibition, and the Kobs[I] is the second-order rate constant for the time dep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281053(CHEMBL430991 | [((2S,5R,6S)-6-Methoxy-3,3-dimethyl...)
Affinity DataKi:  5.30E+4nMAssay Description:Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280496(4-((2S,3S)-3-Ethyl-4-oxo-azetidin-2-yloxy)-benzoic...)
Affinity DataKi:  2.90E+5nMAssay Description:Concentration required for inhibition of human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015924(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015885(3-Acetoxymethyl-7-chloro-5,5,8-trioxo-5lambda*6*-t...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281044((2S,5R,6S)-3,3-Dimethyl-4,4,7-trioxo-6-(toluene-4-...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration required against Human Leukocyte Elastase (HLE) for 50% reduction in rate of hydrolysis of (suc-Ala-Ala-Pro-Ala-p-NA) peptid...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015871(3-Acetoxymethyl-7-fluoro-5,5,8-trioxo-5lambda*6*-t...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015916(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281037((2S,5R,6S)-3,3-Dimethyl-4,4,7-trioxo-6-(2,2,2-trif...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration required against Human Leukocyte Elastase (HLE) for 50% reduction in rate of hydrolysis of (suc-Ala-Ala-Pro-Ala-p-NA) peptid...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015922(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015913(Acetic acid 2-(benzyl-methyl-carbamoyl)-7-methoxy-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015912(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015904(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015900(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015935(3-(1-Carboxy-2-phenyl-ethylcarbamoyloxymethyl)-7-m...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281041((2S,5R,6S)-3,3-Dimethyl-4,4,7-trioxo-6-(2,2,2-trif...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration required against Human Leukocyte Elastase (HLE) for 50% reduction in rate of hydrolysis of (suc-Ala-Ala-Pro-Ala-p-NA) peptid...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015920(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281024((2S,5R,6S)-3,3-Dimethyl-6-[methyl-(2,2,2-trifluoro...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration required against Human Leukocyte Elastase (HLE) for 50% reduction in rate of hydrolysis of (suc-Ala-Ala-Pro-Ala-p-NA) peptid...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015909(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015921(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015919(4-[(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015907(CHEMBL432765 | [(3-Acetoxymethyl-7-methoxy-5,5,8-t...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281025((2S,5R,6S)-6-Acetoxy-3,3-dimethyl-4,4,7-trioxo-4la...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration required against Human Leukocyte Elastase (HLE) for 50% reduction in rate of hydrolysis of (suc-Ala-Ala-Pro-Ala-p-NA) peptid...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50403123(CHEMBL2115563)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration required against Human Leukocyte Elastase (HLE) for 50% reduction in rate of hydrolysis of (suc-Ala-Ala-Pro-Ala-p-NA) peptid...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015856(3-Acetoxymethyl-7-formyloxy-5,5,8-trioxo-5lambda*6...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015914((6R,7S)-3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5la...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015915(4-{[((6R,7S)-3-Acetoxymethyl-7-methoxy-5,5,8-triox...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015901(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015923(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50015856(3-Acetoxymethyl-7-formyloxy-5,5,8-trioxo-5lambda*6...)
Affinity DataIC50:  400nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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