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Found 369 with Last Name = 'barvian' and Initial = 'mr'
LigandPNGBDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50:  2nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6326(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-morpholin-4-y...)
Affinity DataIC50:  4nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6570(6-(2,6-dichlorophenyl)-2-[(4-ethoxyphenyl)amino]-8...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6571(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6572(6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6324(6-Acetyl-8-cyclopentyl-5-methyl-2-(3,4,5,6-tetrahy...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6321(6-Acetyl-8-cyclopentyl-5-methyl-2-[5-(4-methyl-pip...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  5.68nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6303(Pyrido-[2,3-d]-pyrimidin-7-one 37 | ethyl 8-cyclop...)
Affinity DataIC50:  6nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50:  7.40nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3453(3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)buty...)
Affinity DataIC50:  7.5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  8.35nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6571(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataIC50:  9.03nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3467(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(4-me...)
Affinity DataIC50:  10nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  11nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6323(6-Acetyl-8-cyclopentyl-2-(5-[1,4]diazepan-1-yl-pyr...)
Affinity DataIC50:  12nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3452(1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50:  12nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6253(8-Cyclopentyl-2-phenylamino-8H-pyrido[2,3-d]pyrimi...)
Affinity DataIC50:  12nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6293(8-Cyclopentyl-6-methoxymethyl-2-(5-piperazin-1-ylp...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6292(8-Cyclopentyl-6-hydroxymethyl-2-(5-piperazin-1-ylp...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6286(8-Cyclohexyl-2-(5-piperazin-1-yl-pyridin-2-ylamino...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6322(2-{[5-(3-aminopyrrolidin-1-yl)pyridin-2-yl]amino}-...)
Affinity DataIC50:  14nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6285(8-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamin...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3479(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  15nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6287(6-Bromo-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin-...)
Affinity DataIC50:  16nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3485(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  16nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3463(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(2-me...)
Affinity DataIC50:  16nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6570(6-(2,6-dichlorophenyl)-2-[(4-ethoxyphenyl)amino]-8...)
Affinity DataIC50:  16.3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6572(6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...)
Affinity DataIC50:  16.8nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3450(1-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)buty...)
Affinity DataIC50:  18nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6294(8-Cyclopentyl-6-ethoxymethyl-2-(5-piperazin-1-yl-p...)
Affinity DataIC50:  18nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3471(1-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  19nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6289(6-Amino-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin-...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6325(6-Acetyl-8-cyclopentyl-2-(4-hydroxy-3,4,5,6-tetrah...)
Affinity DataIC50:  19nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3477(1-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  20nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6319(6-Acetyl-8-cyclopentyl-2-[5-(3,3-dimethyl-piperazi...)
Affinity DataIC50:  21nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3501(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  22nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3497(6-arylpyrido[2,3-d]pyrimidine deriv. 79 | N-[6-(2,...)
Affinity DataIC50:  22nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3493(3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)buty...)
Affinity DataIC50:  22nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3470(1-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  22nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6291(8-Cyclopentyl-6-ethyl-2-(5-piperazin-1-yl-pyridin-...)
Affinity DataIC50:  22nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3469(1-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  24nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50:  24.5nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6290(8-Cyclopentyl-6-methyl-2-(5-piperazin-1-yl-pyridin...)
Affinity DataIC50:  27nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3474(1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-me...)
Affinity DataIC50:  29nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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