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Found 62 with Last Name = 'becker-pelster' and Initial = 'em'
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317598(US9624199, 8 | {6-[(2,6-Difluorobenzyl)(methyl)ami...)
Affinity DataIC50:  4.5nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398510((rac)-{2-[(1-Methoxybutan-2-yl)amino]pyrimidin-5-y...)
Affinity DataIC50:  5nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317578(US9624198, 3 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...)
Affinity DataIC50:  9nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317585(US9624198, 10 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50:  11nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317586(US9624198, 11 | US9624198, 12 | [4-(3,4-Dihydroiso...)
Affinity DataIC50:  11nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317584(US9624198, 9 | [4-(6-Methoxy-3,4-dihydroisoquinoli...)
Affinity DataIC50:  11nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317593(US9624199, 3 | {6-[(2R)-2-(Methoxymethyl)pyrrolidi...)
Affinity DataIC50:  11nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317603(US9624199, 13 | [6-(3-Methoxypyrrolidin-1-yl)pyrid...)
Affinity DataIC50:  12nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317597(US9624199, 7 | [3-(Cyclopropylmethoxy)-1,4′-...)
Affinity DataIC50:  13nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317577(US9624198, 2 | [4-(7-Fluoro-3,4-dihydroisoquinolin...)
Affinity DataIC50:  13nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317607(US9624199, 17 | [3-(Cyclopropylmethoxy)-1,4′...)
Affinity DataIC50:  14nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317604(US9624199, 14 | {6-[(1-Methoxybutan-2-yl)amino]pyr...)
Affinity DataIC50:  16nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398515(US10323020, Example 9 | [4-(7-Fluoro-3,4-dihydrois...)
Affinity DataIC50:  16nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317595(US9624199, 5 | [6-(4,4-Difluoropiperidin-1-yl)pyri...)
Affinity DataIC50:  18nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317600((6-{[(2 S)-1-Hydroxybutan-2-yl]amino}pyridin-3-yl)...)
Affinity DataIC50:  18nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317609(US9624199, 19 | [2-(4,4-Difluoropiperidin-1-yl)pyr...)
Affinity DataIC50:  19nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398511((rac)-{2-[(1-Methoxybutan-2-yl)amino]pyrimidin-5-y...)
Affinity DataIC50:  20nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317602(2-[(5-{[(3R)-3-Methyl-1,4′-bipiperidin-1R...)
Affinity DataIC50:  21nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317586(US9624198, 11 | US9624198, 12 | [4-(3,4-Dihydroiso...)
Affinity DataIC50:  21nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317582(US9624198, 7 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...)
Affinity DataIC50:  21nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317576( [4-(3,4-Dihydroisoquinolin-2-(1H)-yl)piperidin-1-...)
Affinity DataIC50:  22nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398514(US10323020, Example 8 | [4-(3,4-Dihydroisoquinolin...)
Affinity DataIC50:  23nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317589(US9624198, 14 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50:  23nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317608(US9624199, 18 | [(3R)-3-Methyl-1,4′-bipiperi...)
Affinity DataIC50:  24nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398508((rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl...)
Affinity DataIC50:  24nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317579(US9624198, 4 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...)
Affinity DataIC50:  24nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398519(US10323020, Example 13 | US10323020, Example 14 | ...)
Affinity DataIC50:  24nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398518(US10323020, Example 12 | [4-(3,4-Dihydroisoquinoli...)
Affinity DataIC50:  26nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398508((rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl...)
Affinity DataIC50:  26nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317581(1-(5-{[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...)
Affinity DataIC50:  27nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317599(US9624199, 9 | [6-(1,1-Dioxidothiomorpholin-4-yl)p...)
Affinity DataIC50:  27nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317605(US9624199, 15 | [(3R)-3-Methyl-1,4′-bipiperi...)
Affinity DataIC50:  27nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317591( [(3R)-3-Methyl-1,4′-bipiperidin-1′-yl...)
Affinity DataIC50:  28nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398516(US10323020, Example 10 | [4-(6-Methoxy-3,4-dihydro...)
Affinity DataIC50:  30nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398512((rac)-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...)
Affinity DataIC50:  31nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317596(US9624199, 6 | {6-[(2-Methoxyethyl)(methyl)amino]p...)
Affinity DataIC50:  33nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317594(US9624199, 4 | {6-[(2-Methoxyethyl)amino]pyridin-3...)
Affinity DataIC50:  36nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317610(US9624199, 20 | {2-[(2R)-2-(Methoxymethyl)pyrrolid...)
Affinity DataIC50:  41nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398519(US10323020, Example 13 | US10323020, Example 14 | ...)
Affinity DataIC50:  47nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317592(US9624199, 2 | [(3R)-3-Methyl-1,4′-bipiperid...)
Affinity DataIC50:  50nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317590(US9624198, 15 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50:  53nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317588(US9624198, 13 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50:  53nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317606(US9624199, 16 | [(3R)-3-Methyl-1,4′-bipiperi...)
Affinity DataIC50:  54nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317583(US9624198, 8 | [4-(6-Fluoro-3,4-dihydroisoquinolin...)
Affinity DataIC50:  58nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317601(US9624199, 11 | {6[(1-Hydroxybutan-2-yl)amino]pyri...)
Affinity DataIC50:  62nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317580(US9624198, 5 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...)
Affinity DataIC50:  65nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398513((rac)-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...)
Affinity DataIC50:  68nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398521(US10323020, Example 15 | [4-(3,4-Dihydroisoquinoli...)
Affinity DataIC50:  68nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM317611(US9624199, 21 | [5-(1,1-Dioxidothiomorpholin-4-yl)...)
Affinity DataIC50:  71nMAssay Description:To prepare cell membranes with human α1- and α2-adrenergic receptors, CHO cells stably overexpressing α1- and α2-adrenergic recep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM398507(US10323020, Example 1 | [4-(3,4-Dihydroisoquinolin...)
Affinity DataIC50:  82nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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