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Found 2740 with Last Name = 'booker' and Initial = 's'
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM164488(US9066954, 373)
Affinity DataKi:  0.100nM ΔG°:  -57.5kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM164473(US9066954, 302)
Affinity DataKi:  0.300nM ΔG°:  -54.7kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383200(CHEMBL2032026)
Affinity DataKi:  0.400nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357645(CHEMBL1738719)
Affinity DataKi:  0.600nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383169(CHEMBL2032014)
Affinity DataKi:  0.600nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383168(CHEMBL2032015)
Affinity DataKi:  0.600nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357674(CHEMBL1914739)
Affinity DataKi:  0.600nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383172(CHEMBL2031912)
Affinity DataKi:  0.600nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM164486(US9066954, 336)
Affinity DataKi:  0.700nM ΔG°:  -52.6kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383206(CHEMBL2032019)
Affinity DataKi:  0.700nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357665(CHEMBL1914728)
Affinity DataKi:  0.700nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357652(CHEMBL1914726)
Affinity DataKi:  0.700nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383194(CHEMBL2032018)
Affinity DataKi:  0.700nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383208(CHEMBL2032016)
Affinity DataKi:  0.800nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351949(CHEMBL1822054)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human N-terminal His-tagged PI3Kdelta expressed in insect Sf9 cells using PI(4,5)P2 as substrate after 20 mins by alphascreen assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383198(CHEMBL2032029)
Affinity DataKi:  0.800nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383195(CHEMBL2032031)
Affinity DataKi:  0.800nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357650(CHEMBL1914742)
Affinity DataKi:  0.800nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357653(CHEMBL1914727)
Affinity DataKi:  0.800nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357668(CHEMBL1914731)
Affinity DataKi:  0.800nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357670(CHEMBL1914734)
Affinity DataKi:  0.800nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383173(CHEMBL2031911)
Affinity DataKi:  0.900nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357666(CHEMBL1914729)
Affinity DataKi:  0.900nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357662(CHEMBL1914721)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM164420(US9066954, 55)
Affinity DataKi:  0.900nM ΔG°:  -52.0kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50357651(CHEMBL1914724)
Affinity DataKi:  0.900nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383197(CHEMBL2029375)
Affinity DataKi:  0.900nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357673(CHEMBL1914738)
Affinity DataKi:  0.900nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50383202(CHEMBL2032023)
Affinity DataKi:  0.900nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357664(CHEMBL1914723)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343205(CHEMBL1773606 | N-(6-(6-Chloro-5-(2-(trifluorometh...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396809(CHEMBL2170099 | US8772480, 147)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396807(CHEMBL2170082 | US8772480, 316)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396806(CHEMBL2170083 | US8772480, 270)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396820(CHEMBL2170088 | US8772480, 272)
Affinity DataKi:  1nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM125442(US8772480, 297)
Affinity DataKi:  1nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM125451(US8772480, 306)
Affinity DataKi:  1nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM125327(US8772480, 150)
Affinity DataKi:  1nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50343209(CHEMBL1773731 | N-(6-(6-Chloro-5-(3-chlorophenylsu...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343208(CHEMBL1773730 | N-(6-(6-Chloro-5-(2-chlorophenylsu...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343207(CHEMBL1773729 | N-(6-(6-Chloro-5-(4-(trifluorometh...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343206(CHEMBL1773728 | N-(6-(6-Chloro-5-(3-(trifluorometh...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357675(CHEMBL1914740)
Affinity DataKi:  1nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357644(CHEMBL1914947)
Affinity DataKi:  1nMAssay Description:Inhibition of N-terminus polyHis-tagged human recombinant PI3Kalpha expressed in baculovirus infected insect Sf9 cells using phosphoinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357667(CHEMBL1914730)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24460(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  1nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24462(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  1nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24466(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Affinity DataKi:  1nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343211(CHEMBL1773733 | N-(6-(5-(3-tert-Butylphenylsulfona...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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