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Found 36 with Last Name = 'borch' and Initial = 'rf'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107343((4-Chloro-butyl)-methyl-phosphoramidic acid 5-(5-f...)
Affinity DataIC50:  1.90nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50:  7.90nMAssay Description:Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107341((4-Chloro-butyl)-methyl-phosphoramidic acid 1,4-di...)
Affinity DataIC50:  10nMAssay Description:Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50476390(CHEMBL426360)
Affinity DataIC50:  13nMAssay Description:Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptideMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50476389(CHEMBL229376)
Affinity DataIC50:  16nMAssay Description:Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptideMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50:  20nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107341((4-Chloro-butyl)-methyl-phosphoramidic acid 1,4-di...)
Affinity DataIC50:  25nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107343((4-Chloro-butyl)-methyl-phosphoramidic acid 5-(5-f...)
Affinity DataIC50:  65nMAssay Description:Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107341((4-Chloro-butyl)-methyl-phosphoramidic acid 1,4-di...)
Affinity DataIC50:  230nMAssay Description:Thymidylate synthase inhibition in wild type LM cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50:  260nMAssay Description:Thymidylate synthase inhibition in wild type LM cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107343((4-Chloro-butyl)-methyl-phosphoramidic acid 5-(5-f...)
Affinity DataIC50:  560nMAssay Description:Thymidylate synthase inhibition in wild type LM cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303967((E)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303973((E)-N-(2-Hydroxyethyl)-3-(3-chloro-1,4-dioxonaphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303964((E)-3-(3-Methoxy-1,4-naphthoquinon-2-yl)-2-methylp...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303972((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methoxyet...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303965((E)-3-(3-Methylthio-1,4-naphthoquinon-2-yl)-2-meth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107343((4-Chloro-butyl)-methyl-phosphoramidic acid 5-(5-f...)
Affinity DataIC50:  1.06E+3nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303969((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303968((Z)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303962((E)-3-(1,4-Naphthoquinon-2-yl)-2-methylpropenoic a...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303959((E)-3-(3-Chloro-5,6-dimethoxy-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303957((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303971((E)-2-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303966((E)-3-(3-Fluoro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303974(3-(3-Bromo-1,4-naphthoquinon-2-yl)-propionic Acid ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50476391(CHEMBL447845)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptideMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50:  5.40E+3nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50107341((4-Chloro-butyl)-methyl-phosphoramidic acid 1,4-di...)
Affinity DataIC50:  5.90E+3nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 h treatmentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303960((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303970((E)-3-(3-Methyl-1,4-naphthoquinon-2-yl)-2-methoxye...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303955((E)-3-(5,6-Dimethoxy-3-methyl-14-dioxocyclohexa-25...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303961((E)-N-(2-Hydroxyethyl)-3-(5,6-dimethoxy-3-methyl-1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303958((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303963((E)-3-(3-Methyl-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303956((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed