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Found 3268 with Last Name = 'brown' and Initial = 'k'
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50080514(3-[(R)-3-(7-Methoxy-naphthalene-2-sulfonylamino)-2...)
Affinity DataKi:  0.0470nMAssay Description:Compound was evaluated for the inhibition of human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 14(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50512416(CHEMBL4447162)
Affinity DataKi:  0.0800nMAssay Description:Antagonist activity at human P2Y14R expressed in CHO cells assessed as inhibition of UDPG-mediated reduction of forskolin-induced [3H]cAMP production...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 14(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50512416(CHEMBL4447162)
Affinity DataKi:  0.0800nMAssay Description:Antagonist activity at human P2Y14R expressed in CHO cells assessed as inhibition of UDPG-mediated reduction of forskolin-induced [3H]cAMP production...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50321606((3S,6S,9S,12S,15R,18S,21S,27R,30S)-18-((1H-imidazo...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50321606((3S,6S,9S,12S,15R,18S,21S,27R,30S)-18-((1H-imidazo...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of human Aurora B ATP binding site by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114539((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[4-(1-oxy-pyr...)
Affinity DataKi:  0.400nMAssay Description:Inibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114534((2R,3R)-3-[(3'-Aminomethyl-biphenyl-4-carbonyl)-am...)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibitory activity against human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085393((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-carbamoy...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114544((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-(4-pyridin-4-...)
Affinity DataKi:  0.5nMAssay Description:Inibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085393((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-carbamoy...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibitory activity against human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114543((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[4-(1-oxy-pyr...)
Affinity DataKi:  0.580nMAssay Description:Inibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50321607((3S,6S,9S,12S,15R,18S,21S,27R,30S)-18-((1H-imidazo...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114536((2R,3R)-3-[(3'-Aminomethyl-biphenyl-4-carbonyl)-am...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibitory activity against human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085402(4-{4-[3-(5-Carbamimidoyl-2-hydroxy-phenyl)-allylca...)
Affinity DataKi:  0.75nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123781(4-(4-Amino-quinazolin-7-ylmethyl)-1-(6-chloro-benz...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 10 mg/kg peroral doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114540(3-{4-[(1R,2R)-3-(3-Carbamimidoyl-phenyl)-2-methoxy...)
Affinity DataKi:  0.800nMAssay Description:Inibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114537((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-(4-pyridin-2-...)
Affinity DataKi:  0.890nMAssay Description:Inibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12597(CHEMBL48046 | RPR128515 | methyl (2R,3R)-2-{3-[ami...)
Affinity DataKi:  0.900nMAssay Description:In vitro inhibitory activity against human Coagulation factor XaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50472023(CHEMBL148384)
Affinity DataKi:  0.933nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50472019(CHEMBL148668)
Affinity DataKi:  0.977nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114531((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-dimethyl...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory activity against human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50111966(1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-benz...)
Affinity DataKi:  1nMAssay Description:Inhibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12594(4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXO...)
Affinity DataKi:  1nMAssay Description:Inhibition of Coagulation factor XaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...Checked by AuthorMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 5 mg/kg peroral doseMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114548(2-{4-[(1R,2R)-3-(3-Carbamimidoyl-phenyl)-2-methoxy...)
Affinity DataKi:  1.20nMAssay Description:Inibition of Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50312651(1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethy...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12594(4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXO...)
Affinity DataKi:  1.30nMAssay Description:Compound was evaluated for the inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081505(3-[(S)-3-(5-Chloro-thieno[3,2-b]pyridine-2-sulfony...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50472043(CHEMBL148596)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50418564(CHEMBL423026)
Affinity DataKi:  1.5nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50321604((3S,6S,9S,12S,15R,18S,21S,24R,27S)-18-((1H-imidazo...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]CCK-8(SO3) from human CCK1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50321604((3S,6S,9S,12S,15R,18S,21S,24R,27S)-18-((1H-imidazo...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]CCK-8(SO3) from human CCK1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50472035(CHEMBL2112870)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50472034(CHEMBL147021)
Affinity DataKi:  1.70nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50312653(1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethy...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50472037(CHEMBL414442)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081499(4-Hydroxy-3-[(S)-2-oxo-3-(thieno[2,3-c]pyridine-2-...)
Affinity DataKi:  2nMAssay Description:Binding affinity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13304(4-hydroxy-3-[((3S)-2-oxo-3-{[(5-pyridin-3-ylthien-...)
Affinity DataKi:  2nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50114528((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[(4'-carbamoy...)
Affinity DataKi:  2nMAssay Description:In vitro inhibitory activity against human Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085405(2'-Sulfamoyl-biphenyl-4-carboxylic acid [3-(5-carb...)
Affinity DataKi:  2nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081512(3-[(S)-3-(4-Chloro-thieno[3,2-c]pyridine-2-sulfony...)
Affinity DataKi:  2nMAssay Description:Binding affinity against serine protease factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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