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Found 796 with Last Name = 'burchat' and Initial = 'a'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: <1nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092249(4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50: <1nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092241(7-tert-Butyl-5-[4-(4-methoxy-phenoxy)-phenyl]-7H-p...)
Affinity DataIC50: <1nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092228(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: <1nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092228(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092225(7-tert-Butyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092256(2-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: <3nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092244(5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: <3nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092240(5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: <3nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092236(CHEMBL71541 | {2-[4-(4-Amino-7-isopropyl-7H-pyrrol...)
Affinity DataIC50: <3nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092254(7-Isopropyl-5-[4-(2-nitro-phenoxy)-phenyl]-7H-pyrr...)
Affinity DataIC50: <3nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092243(CHEMBL70034 | {4-[4-(4-Amino-7-isopropyl-7H-pyrrol...)
Affinity DataIC50: <3nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM8798(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235829(CHEMBL4098474)
Affinity DataIC50:  5nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235828(CHEMBL4090753)
Affinity DataIC50:  5nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092235(5-[4-(2-Amino-phenoxy)-phenyl]-7-isopropyl-7H-pyrr...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092239(7-Cyclopentyl-5-[4-(2-methoxy-phenoxy)-phenyl]-7H-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235831(CHEMBL4093260)
Affinity DataIC50:  6nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235816(CHEMBL4069365)
Affinity DataIC50:  7nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092234(2-[4-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50:  8nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235816(CHEMBL4069365)
Affinity DataIC50:  9nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM8807(CHEMBL43773 | N-(4-{4-amino-1-[4-(4-methylpiperazi...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50338159(2-(6-(2-chloro-4-(methylsulfonyl)benzyl)-5-methyl-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092252(6-Chloro-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyr...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235818(CHEMBL4071441)
Affinity DataIC50:  12nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

LigandPNGBDBM8798(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Affinity DataIC50:  12.5nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235821(CHEMBL4100939)
Affinity DataIC50:  13nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50175210(CHEMBL199438 | N-(4-(4-amino-1-(1-(tetrahydro-2H-p...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092225(7-tert-Butyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  14nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092240(5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092249(4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  17nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092250(CHEMBL302279 | [4-Amino-7-cyclopentyl-5-(4-phenoxy...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM8806((1R,2R)-N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092244(5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50:  19nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305013(3-(2-amino-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092239(7-Cyclopentyl-5-[4-(2-methoxy-phenoxy)-phenyl]-7H-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50175200(CHEMBL371295 | N-(4-(4-amino-1-(1-(1-methylpiperid...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092246(4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50338157(2-(6-(4-(N-cyclohexyl-N-methylsulfamoyl)benzyl)-5-...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235827(CHEMBL4081974)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration required against 5-lipoxygenase activity in cytosolic fractions of human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50175200(CHEMBL371295 | N-(4-(4-amino-1-(1-(1-methylpiperid...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50:  23nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50:  24nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

LigandPNGBDBM8806((1R,2R)-N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  27nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM8803(CHEMBL295601 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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