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Found 838 with Last Name = 'cadogan' and Initial = 'e'
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by HTRF as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413448(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Affinity DataIC50:  0.0794nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599239(CHEMBL5184141 | US11884671, Example 32)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599238(CHEMBL5181303 | US11884671, Example 29)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599237(CHEMBL5180090 | US11884671, Example 30)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599240(CHEMBL5194436 | US11884671, Example 31)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413460(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Affinity DataIC50:  0.158nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245500(US9428503, 28)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419668(CHEMBL1947157)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50526936(CHEMBL4450232)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419678(CHEMBL1945036)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245505(US9428503, 33)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245478(US9428503, 5)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245514(US9428503, 42)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245475(US9428503, 2)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50526938(CHEMBL4553941)
Affinity DataIC50:  0.251nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459004(CHEMBL4217549)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate pretreated for 30 mins followed by substrate addition and measured after 2 hrs by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245510(US9428503, 38)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50526928(CHEMBL4555040)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413456(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245490(US9428503, 17)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599247(CHEMBL5197250)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50526932(CHEMBL4474647)
Affinity DataIC50:  0.398nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413457(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Affinity DataIC50:  0.398nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459016(CHEMBL4210045)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 residue in human HT-29 cells measured after 1 hr by Hoechst staining based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419702(CHEMBL1945038)
Affinity DataIC50:  0.501nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419670(CHEMBL1944691)
Affinity DataIC50:  0.501nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599234(CHEMBL5170489 | US11884671, Example 52)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459018(CHEMBL4166405)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419669(CHEMBL1944690)
Affinity DataIC50:  0.631nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419710(CHEMBL1946768)
Affinity DataIC50:  0.631nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419674(CHEMBL1945031)
Affinity DataIC50:  0.631nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599248(CHEMBL5179972)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599242(CHEMBL5196848 | US11884671, Example 45)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599243(CHEMBL5192430 | US11884671, Example 37)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to human untagged DNA-PK expressed in baculovirus expression system measured after 60 mins by Lan...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459003(CHEMBL4218854)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate pretreated for 30 mins followed by substrate addition and measured after 2 hrs by HTRF assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599245(CHEMBL5191577)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245491(US9428503, 18)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245481(US9428503, 8)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419671(CHEMBL1944693)
Affinity DataIC50:  0.794nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419679(CHEMBL1945037)
Affinity DataIC50:  0.794nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419687(CHEMBL1947151)
Affinity DataIC50:  0.794nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535970(CHEMBL4569967)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459014(CHEMBL4212961)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 residue in human HT-29 cells measured after 1 hr by Hoechst staining based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245489(US9428503, 16)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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