Compile Data Set for Download or QSAR
maximum 50k data
Found 611 with Last Name = 'cai' and Initial = 'sx'
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50056605(7-Chloro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-...)
Affinity DataIC50:  4.70nMAssay Description:Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161456(3-[(S)-2-(2,5-Dichloro-phenylcarbamoyloxy)-3-methy...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  5nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-9 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50038161(6,7-Dichloro-3-hydroxy-5-nitro-3,4-dihydro-1H-quin...)
Affinity DataIC50:  5.90nMAssay Description:Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human caspase 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Epicept

Curated by ChEMBL
LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161460(5-Fluoro-3-[(S)-2-(3-fluoro-phenylcarbamoyloxy)-3-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Epicept

Curated by ChEMBL
LigandPNGBDBM50153668(3-[(S)-2-(2,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  6nMAssay Description:Inhibition concentration required against caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Epicept

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  7nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  7nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-7 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052635(5,6,7-Trichloro-1H-quinoline-2,3,4-trione 3-oxime ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066544(4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol | CHEMBL...)
Affinity DataIC50:  8nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50056596(7-Bromo-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2...)
Affinity DataIC50:  8.70nMAssay Description:Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153668(3-[(S)-2-(2,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  9nMAssay Description:Inhibition concentration required against caspase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080029(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Affinity DataIC50:  9nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
TargetCaspase-7(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153668(3-[(S)-2-(2,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  10nMAssay Description:Inhibition concentration required against caspase-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50369783(CHEMBL1203902)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161452(5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-buty...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against Caspase-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50085922(4-(4-Hydroxy-phenyl)-1-(4-phenyl-butyl)-piperidin-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052629(6,7-Dichloro-1H-quinoline-2,3,4-trione 3-oxime | C...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Epicept

Curated by ChEMBL
LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161461(5-Fluoro-3-[(S)-3-methyl-2-(4-phenoxy-phenylcarbam...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161454(3-[(S)-2-(3,4-Difluoro-phenylcarbamoyloxy)-3-methy...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161465(3-[(S)-2-(2,4-Dichloro-phenylcarbamoyloxy)-3-methy...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153666(3-[(S)-2-(2,5-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066538(4-[3-(4-Phenyl-butylamino)-propyl]-phenol | CHEMBL...)
Affinity DataIC50:  15nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50085933(4-[1-(5-Phenyl-pentyl)-pyrrolidin-3-yl]-phenol | C...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161452(5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-buty...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Epicept

Curated by ChEMBL
LigandPNGBDBM50161452(5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-buty...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  18nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-6 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50369786(CHEMBL1201889)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161455(5-Fluoro-3-[(S)-2-(4-fluoro-phenylcarbamoyloxy)-3-...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50085927(4-[1-(2-Hydroxy-4-phenyl-butyl)-piperidin-4-yl]-ph...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Epicept

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161457(2,6-Dichloro-benzoic acid 4-carboxy-3-((S)-3-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161453(3-((S)-2-Benzylcarbamoyloxy-3-methyl-butyrylamino)...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against human caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50056618(6,7-Dibromo-5-nitro-1,4-dihydro-quinoxaline-2,3-di...)
Affinity DataIC50:  20nMAssay Description:Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153679(3-[(S)-2-(3,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against human recombinant caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50369791(CHEMBL1202296)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153668(3-[(S)-2-(2,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50079386(4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol | 4-...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50085929(4-(4-Hydroxy-phenyl)-1-(2-hydroxy-4-phenyl-butyl)-...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153673(5-Fluoro-3-[(S)-2-(4-fluoro-benzyloxycarbonylamino...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against human recombinant caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50079389(4-{2-[4-(4-Methyl-benzyl)-piperidin-1-yl]-ethoxy}-...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50056595(6,7-Dimethyl-5-nitro-1,4-dihydro-quinoxaline-2,3-d...)
Affinity DataIC50:  29nMAssay Description:Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50153674(5-Fluoro-3-[(S)-2-(3-fluoro-benzyloxycarbonylamino...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against human recombinant caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50056620(6-Chloro-7-ethyl-5-nitro-1,4-dihydro-quinoxaline-2...)
Affinity DataIC50:  29nMAssay Description:Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052627(5,6,7-Trichloro-1,4-dihydro-quinoxaline-2,3-dione ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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