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Found 122 with Last Name = 'callaghan' and Initial = 'o'
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139913(US8895745, 375)
Affinity DataIC50:  0.490nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139918(US8895745, 401)
Affinity DataIC50:  0.704nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139909(US8895745, 310)
Affinity DataIC50:  0.780nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139914(US8895745, 378)
Affinity DataIC50:  0.790nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139920(US8895745, 412)
Affinity DataIC50:  1.24nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139924(US8895745, 402)
Affinity DataIC50:  1.60nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139915(US8895745, 384)
Affinity DataIC50:  1.90nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139921(US8895745, 416)
Affinity DataIC50:  2.18nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139922(US8895745, 421)
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139908(US8895745, 59)
Affinity DataIC50:  3.30nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139923(US8895745, 422)
Affinity DataIC50:  3.30nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139917(US8895745, 399)
Affinity DataIC50:  4.74nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139910(US8895745, 329)
Affinity DataIC50:  15.8nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139912(US8895745, 359)
Affinity DataIC50:  16.4nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139916(US8895745, 396)
Affinity DataIC50:  18.3nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataIC50:  20nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139911(US8895745, 354)
Affinity DataIC50:  22.2nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM139919(US8895745, 407)
Affinity DataIC50:  31nMpH: 7.5Assay Description:Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147422(3-(4-Chloro-1-guanidino-isoquinolin-7-yl)-benzoic ...)
Affinity DataIC50:  37nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231528(4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-(piperidi...)
Affinity DataIC50:  72nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  380nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM23891(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231527((R)-N-[(3-chloro-2-ethoxy 5-(1-piperidinyl)phenyl]...)
Affinity DataIC50:  460nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231526(4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphen...)
Affinity DataIC50:  520nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  640nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM15786(3-N-{[2-(benzyloxy)-5-(1H-indol-6-yl)phenyl]methyl...)
Affinity DataIC50:  690nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231523(CHEMBL253607 | N-[(3,5-di-isopropoxy)phenyl] 4-[(2...)
Affinity DataIC50:  720nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231529(4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimet...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231524(CHEMBL401366 | N-[(3-fluoro-5-(4-morpholinyl)pheny...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226455(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimeth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226455(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimeth...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231525(CHEMBL253379 | N-[3-(isopropyloxy)phenyl] 4-[(2-am...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM15787(3-N-{[5-(1H-indol-6-yl)-2-(pyridin-2-ylmethoxy)phe...)
Affinity DataIC50:  4.20E+3nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231519(4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOX...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM15785(3-N-{[3-(1H-indol-6-yl)phenyl]methyl}pyridine-2,3-...)
Affinity DataIC50:  9.10E+3nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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