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Found 177 with Last Name = 'castle' and Initial = 'na'
TargetCalcium-activated potassium channel subunit beta(GUINEA PIG)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86250(CAS_60559-98-0 | NSC_43345 | P1075)
Affinity DataKi:  10.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity choline transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]Dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  2.12E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287520(CHEMBL4159883)
Affinity DataKi:  2.80E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287520(CHEMBL4159883)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287558(CHEMBL1333494)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287559(CHEMBL4170197)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287552(CHEMBL4175004)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287556(CHEMBL4161489)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287519(CHEMBL4172084)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287553(CHEMBL4166791)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287554(CHEMBL4162926)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287557(CHEMBL4159568)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451457(CHEMBL4210135)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451458(CHEMBL4205773)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451456(CHEMBL4215058)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451458(CHEMBL4205773)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451454(CHEMBL4207534)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451459(CHEMBL4208664)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451453(CHEMBL2325603)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451448(CHEMBL4213464)
Affinity DataIC50: <4nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451460(CHEMBL4215917)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451455(CHEMBL2325325)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451452(CHEMBL2321912)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451450(CHEMBL4208535)
Affinity DataIC50: <10nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells by voltage clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451449(CHEMBL4213602)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287519(CHEMBL4172084)
Affinity DataIC50:  32nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287519(CHEMBL4172084)
Affinity DataIC50:  35nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287520(CHEMBL4159883)
Affinity DataIC50:  61nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50:  62nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50258540(CHEMBL468514 | N-((7R,8R)-7-hydroxy-8-(4-pentylphe...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  75nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50:  85nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50:  85nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287552(CHEMBL4175004)
Affinity DataIC50:  86nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287552(CHEMBL4175004)
Affinity DataIC50:  86nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50258501(CHEMBL466838 | N-((7R,8R)-7-hydroxy-8-(4-propylphe...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287553(CHEMBL4166791)
Affinity DataIC50:  100nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287556(CHEMBL4161489)
Affinity DataIC50:  104nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50287553(CHEMBL4166791)
Affinity DataIC50:  110nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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