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Found 114 with Last Name = 'chen' and Initial = 'js'
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576790(CHEBI:75419 | CHEMBL376027)
Affinity DataKi:  6.00E+4nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50003240(2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-te...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50226272(CHEMBL3349944)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50226270(CHEMBL3349956)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50226271(CHEMBL3349955)
Affinity DataIC50:  1.90nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024628(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50003235(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024637(2,2-Diethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tet...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024642(3-Methyl-but-3-enoic acid 8-[2-(4-hydroxy-6-oxo-te...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024630(4,4,4-Trifluoro-3-methyl-butyric acid 8-[2-(4-hydr...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024638(Adamantane-1-carboxylic acid 8-[2-(4-hydroxy-6-oxo...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024629(3-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024627(2-Ethyl-2-methyl-butyric acid 8-[2-(4-hydroxy-6-ox...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024633(CHEMBL3349958 | Decanoic acid 8-[2-(4-hydroxy-6-ox...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  16nMAssay Description:Inhibition of DPP4 (unknown origin) pre-incubated for 1 hr before Gly-Pro-pNA substrate addition and measured 2 hrs post substrate additionMore data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50009413(CHEMBL3085466 | Phenyl-acetic acid 8-[2-(4-hydroxy...)
Affinity DataIC50:  19nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024639(3-Methyl-but-2-enoic acid 8-[2-(4-hydroxy-6-oxo-te...)
Affinity DataIC50:  27nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50067718(CHEMBL3402129)
Affinity DataIC50:  36nMAssay Description:Inhibition of DPP4 (unknown origin) pre-incubated for 1 hr before Gly-Pro-pNA substrate addition and measured 2 hrs post substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024635(4-Fluoro-benzoic acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50:  37nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024636(CHEMBL3349953 | Cyclopropanecarboxylic acid 8-[2-(...)
Affinity DataIC50:  39nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024631(CHEMBL3349947 | Carbonic acid 8-[2-(4-hydroxy-6-ox...)
Affinity DataIC50:  83nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50:  183nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50067716(CHEMBL3402120)
Affinity DataIC50:  230nMAssay Description:Inhibition of DPP4 (unknown origin) pre-incubated for 1 hr before Gly-Pro-pNA substrate addition and measured 2 hrs post substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024626(CHEMBL3349957 | Pentanoic acid 8-[2-(4-hydroxy-6-o...)
Affinity DataIC50:  269nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024634(Acetic acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran...)
Affinity DataIC50:  295nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576781(CHEMBL4860434)
Affinity DataIC50:  300nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576781(CHEMBL4860434)
Affinity DataIC50:  300nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM23274((2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamid...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain using SNAPtide as substrate by FRET based assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576781(CHEMBL4860434)
Affinity DataIC50:  340nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123742(CHEMBL412946 | Cyclosporin A analogue)
Affinity DataIC50:  348nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (morn)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123747(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  363nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50067715(CHEMBL3402118)
Affinity DataIC50:  500nMAssay Description:Inhibition of DPP4 (unknown origin) pre-incubated for 1 hr before Gly-Pro-pNA substrate addition and measured 2 hrs post substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123748(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  581nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50445604(CHEMBL3103448)
Affinity DataIC50:  590nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50445604(CHEMBL3103448)
Affinity DataIC50:  590nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123744(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  636nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50067717(CHEMBL3402125)
Affinity DataIC50:  640nMAssay Description:Inhibition of DPP4 (unknown origin) pre-incubated for 1 hr before Gly-Pro-pNA substrate addition and measured 2 hrs post substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123738(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  742nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (morn)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576777(CHEMBL4854965)
Affinity DataIC50:  800nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576777(CHEMBL4854965)
Affinity DataIC50:  800nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123741(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  840nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123743(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  890nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50445604(CHEMBL3103448)
Affinity DataIC50:  940nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50429169(CHEMBL2336719)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Clostridium botulinum BoNT/A using SNAP-25 (66-mer) as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576777(CHEMBL4854965)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Collaborative Innovation Center Of Functionalized Probes For Chemical Imaging In University Of Shandong

Curated by ChEMBL
LigandPNGBDBM50593885(CHEMBL5195751)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of bovine XOD assessed as inhibition of uric acid formation using xanthine as substrate preincubated with enzyme for 5 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123746(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  1.54E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Collaborative Innovation Center Of Functionalized Probes For Chemical Imaging In University Of Shandong

Curated by ChEMBL
LigandPNGBDBM50593892(CHEMBL5182310)
Affinity DataIC50:  1.86E+3nMAssay Description:Inhibition of bovine XOD assessed as inhibition of uric acid formation using xanthine as substrate preincubated with enzyme for 5 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Scripps Research

Curated by ChEMBL
LigandPNGBDBM50576771(CHEMBL4861536)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Homo sapiens (Human))
Enanta Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123738(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50:  1.92E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (MOM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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