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Found 129 with Last Name = 'chen' and Initial = 'ml'
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against LTA 4 hydrolase in aminopeptidase assayMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataKi:  18nMAssay Description:Inhibitory activity against LTA 4 hydrolase in epoxide hydrolase assayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50296704(3-{4-[2-Amino-6-(4-benzyl-piperazin-1-yl)-pyrimidi...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of mouse liver microsome 11betaHSD1 reductase activity expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of cSrc (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285632((S)-2-[((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285639((S)-2-((R)-2-Cyclohexylmethyl-3-hydroxycarbamoyl-p...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
TBA

Curated by ChEMBL
LigandPNGBDBM50024101((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Affinity DataIC50:  7.90nMAssay Description:Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285636((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271947(6-Methoxy-7-[2-(4-methylpiperazin-1-yl)-ethoxy]-4-...)
Affinity DataIC50:  9.23nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285630((S)-2-((R)-2-Benzyl-3-hydroxycarbamoyl-propionylam...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285640((S)-2-((R)-2-Benzyl-3-hydroxycarbamoyl-propionylam...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285637((R)-2-((R)-2-Benzyl-3-hydroxycarbamoyl-propionylam...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312743(3-(5-methoxy-6-(4-methoxybenzyloxy)pyridin-3-yloxy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50185127((3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en...)
Affinity DataIC50:  15nMAssay Description:Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271896(6-Methyl-7-[3-(piperidin-1-yl)-propoxy]-4-(6-methy...)
Affinity DataIC50:  15.4nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271896(6-Methyl-7-[3-(piperidin-1-yl)-propoxy]-4-(6-methy...)
Affinity DataIC50:  15.4nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275877(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methoxy-7-(...)
Affinity DataIC50:  20.7nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285635((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312742(3-((5-methoxy-6-(4-methoxybenzyloxy)pyridin-3-yl)m...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275756(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(2...)
Affinity DataIC50:  34.8nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275812(4-(2-aminobenzo[d]thiazol-6-ylamino)-7-(3-(3,5-dim...)
Affinity DataIC50:  36.6nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312735((S)-(4-(5-amino-6-(2,6-dichlorobenzylamino)pyrazin...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275813(4-(2-aminobenzo[d]thiazol-6-ylamino)-7-(3-(diethyl...)
Affinity DataIC50:  42nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50:  45nMAssay Description:Inhibition of human 11betaHSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
TBA

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50:  46nMAssay Description:Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275757(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(3...)
Affinity DataIC50:  50.6nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275811(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(3...)
Affinity DataIC50:  53.4nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312740(3-(3-methoxy-4-(4-methoxybenzyloxy)benzyloxy)-5-(1...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312736((S)-(4-(5-amino-6-(2,6-dichlorobenzyloxy)pyrazin-2...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271839(6-Methyl-7-[3-(4-methylpiperazin-1-yl)-propoxy]-4-...)
Affinity DataIC50:  75.9nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275758(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(3...)
Affinity DataIC50:  81.1nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271897(6-Methyl-7-[3-(4-methylpiperazin-1-yl)-propoxy]-4-...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50:  122nMAssay Description:Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275759(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(3...)
Affinity DataIC50:  129nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271948(6-Methoxy-7-[3-(4-methylpiperazin-1-yl)-propoxy]-4...)
Affinity DataIC50:  133nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275875(4-(2-amino-1H-benzo[d]imidazol-6-ylamino)-7-(3-(di...)
Affinity DataIC50:  143nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312741(3-((4-methoxy-5-(4-methoxybenzyloxy)pyridin-2-yl)m...)
Affinity DataIC50:  143nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275876(4-(2-amino-1H-benzo[d]imidazol-6-ylamino)-6-methyl...)
Affinity DataIC50:  159nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271840(6-Methyl-7-(3-morpholinopropoxy)-4-(benzothiazol-2...)
Affinity DataIC50:  172nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271900(6-Methoxy-7-[3-(4-methylpiperazin-1-yl)-propoxy]-4...)
Affinity DataIC50:  178nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271899(6-Methoxy-7-[3-(4-methylpiperazin-1-yl)-propoxy]-4...)
Affinity DataIC50:  186nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50024101((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271841(6-Methyl-7-[3-(piperidin-1-yl)-propoxy]-4-(benzoth...)
Affinity DataIC50:  209nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275814(4-(2-aminobenzo[d]thiazol-6-ylamino)-7-(3-(3,5-dim...)
Affinity DataIC50:  267nMAssay Description:Inhibition of cSrc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285633((R)-3-Benzyl-N-((S)-1-carboxy-ethyl)-succinamic ac...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50312737(CHEMBL1088040 | N2-(2,6-dichlorobenzyl)-6-(1-methy...)
Affinity DataIC50:  345nMAssay Description:Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50271945(6-Methoxy-7-[2-(piperidin-1-yl)-ethoxyl]-4-(benzot...)
Affinity DataIC50:  371nMAssay Description:Inhibition of human recombinant cSrc by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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