Compile Data Set for Download or QSAR
maximum 50k data
Found 295 with Last Name = 'chen' and Initial = 'wc'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324676((R)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  18nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of SEW2871-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11233(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  53nM ΔG°:  -41.5kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11232(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438750(CHEMBL2414884)
Affinity DataKi:  71nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324676((R)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  77nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of S1P-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438752(CHEMBL2414882)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438754(CHEMBL2414880)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11231(N-[(benzyloxy)carbonyl]-L-valyl-N1-((1S,2E)-4-etho...)
Affinity DataKi:  660nM ΔG°:  -35.3kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438753(CHEMBL2414881)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438748(CHEMBL2414879)
Affinity DataKi:  1.10E+3nMAssay Description:Non-competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM18358((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Affinity DataKi:  1.30E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM50375511(CHEMBL406973)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234559(CHEMBL4081664)
Affinity DataKi:  2.00E+3nMAssay Description:Non-competitive inhibition of recombinant human alpha GAL-A using varying levels of 4-methylumbelliferyl alpha-D-galactopyranoside substrate at pH 7 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11230(AG7088 analogue 2d | CHEMBL277716 | N-[(benzyloxy)...)
Affinity DataKi:  2.26E+3nM ΔG°:  -32.2kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324677((S)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  2.84E+3nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of SEW2871-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438751(CHEMBL2414883)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290908(CHEMBL4160428)
Affinity DataKi:  3.50E+3nMAssay Description:Competitive inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438749(CHEMBL2414888)
Affinity DataKi:  4.10E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324677((S)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  4.63E+3nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of S1P-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM50375510(CHEMBL405957)
Affinity DataKi:  6.40E+3nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234559(CHEMBL4081664)
Affinity DataKi:  7.70E+3nMAssay Description:Non-competitive inhibition of recombinant human alpha GAL-A using varying levels of 4-methylumbelliferyl alpha-D-galactopyranoside substrate at pH 4....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Taigen Biotechnology

LigandPNGBDBM11229(AG7088 analogue 2a | CHEMBL20636 | N-[(5-methyliso...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataKi:  1.15E+5nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.121nMAssay Description:Inhibition of human PIM3 using RSRHSSYPAGT as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11694((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)
Affinity DataIC50:  12nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11719((2S)-1-(2-{[4-(2,3-dihydro-1H-isoindol-2-yl)-2-met...)
Affinity DataIC50:  15nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11718((2S)-1-(2-{[4-(6,8-difluoro-1,2,3,4-tetrahydroisoq...)
Affinity DataIC50:  22nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11694((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)
Affinity DataIC50:  27nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11717((2S)-1-(2-{[4-(6-fluoro-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  30nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11716((2S)-1-(2-{[2-methyl-4-oxo-4-(1,2,3,4-tetrahydrois...)
Affinity DataIC50:  49nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  51nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11113(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Affinity DataIC50:  53nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50099009((3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidi...)
Affinity DataIC50:  53nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11714((2S)-1-(2-{[(2S)-4-oxo-4-(1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  54nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11699((2S)-1-(2-{[3-(6-fluoro-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50:  83nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataIC50:  92nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179235(2-{5-[4-(7-propyl-3-trifluoromethylbenzo[d]isoxazo...)
Affinity DataIC50:  105nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11697((2S)-1-(2-{[3-oxo-3-(1,2,3,4-tetrahydroisoquinolin...)
Affinity DataIC50:  116nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11710((2S)-Cyanopyrrolidine analogue 18n | 3-({2-[(2S)-2...)
Affinity DataIC50:  119nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179229(2-{5-[3-(3-phenyl-7-propylbenzo[d]isoxazol-6-yloxy...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179225(2-{4-[3-(3-phenyl-7-propylbenzo[d]isoxazol-6-yloxy...)
Affinity DataIC50:  127nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11700((2S)-1-(2-{[3-(2,3-dihydro-1H-isoindol-2-yl)-3-oxo...)
Affinity DataIC50:  132nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179236(2-(5-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50:  152nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11701((2S)-1-{2-[(3-{4-[(3,5-difluorophenyl)carbonyl]pip...)
Affinity DataIC50:  202nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11712((2S)-Cyanopyrrolidine analogue 18p | 3-({2-[(2S)-2...)
Affinity DataIC50:  298nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11706((2S)-Cyanopyrrolidine analogue 18j | 3-({2-[(2S)-2...)
Affinity DataIC50:  317nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM11708((2S)-Cyanopyrrolidine analogue 18l | 3-({2-[(2S)-2...)
Affinity DataIC50:  369nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 295 total ) | Next | Last >>
Jump to: