BindingDB PrimarySearch_ki

Found 107 with Last Name = 'chen' and Initial = 'yp'

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 8.70nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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3D Structure (crystal)

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521389(CHEMBL4468399)

IC50: 13nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521392(CHEMBL4515145)

IC50: 15nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521395(CHEMBL4564974)

IC50: 19nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521398(CHEMBL4450464)

IC50: 20nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521396(CHEMBL4436823)

IC50: 24nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521388(CHEMBL4544864)

IC50: 49nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50041010(BAY-736691 | CHEMBL1513993)

IC50: 50nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521397(CHEMBL4465401)

IC50: 88nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521394(CHEMBL4457086)

IC50: 91nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521393(CHEMBL4445082)

IC50: 100nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521387(CHEMBL4435082)

IC50: 103nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521386(CHEMBL4543521)

IC50: 112nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540157(CHEMBL4641481)

IC50: 160nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521391(CHEMBL4537603)

IC50: 227nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540149(CHEMBL4639799)

IC50: 430nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521390(CHEMBL4453141)

IC50: 594nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521394(CHEMBL4457086)

IC50: 700nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540157(CHEMBL4641481)

IC50: 720nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540151(CHEMBL3580417)

IC50: 1.19E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521389(CHEMBL4468399)

IC50: 1.20E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521395(CHEMBL4564974)

IC50: 1.20E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 1.30E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521386(CHEMBL4543521)

IC50: 1.40E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521390(CHEMBL4453141)

IC50: 1.40E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540159(CHEMBL4642757)

IC50: 1.45E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)

IC50: 1.51E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521391(CHEMBL4537603)

IC50: 1.70E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521398(CHEMBL4450464)

IC50: 1.80E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521396(CHEMBL4436823)

IC50: 2.00E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540156(CHEMBL4642522)

IC50: 2.09E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Amyloid-beta precursor protein(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50492613(CHEMBL2408099)

IC50: 2.20E+3nMAssay Description:Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence methodMore data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521397(CHEMBL4465401)

IC50: 2.20E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521387(CHEMBL4435082)

IC50: 2.40E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540152(CHEMBL4638069)

IC50: 2.96E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Amyloid-beta precursor protein(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50492623(CHEMBL2408101)

IC50: 3.20E+3nMAssay Description:Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540158(CHEMBL4634509)

IC50: 3.22E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540149(CHEMBL4639799)

IC50: 3.71E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 4.01E+3nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540162(CHEMBL4634179)

IC50: 4.23E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540161(CHEMBL4641208)

IC50: 4.26E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540153(CHEMBL4642989)

IC50: 4.31E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540160(CHEMBL4646479)

IC50: 4.32E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
Henan University

Curated by ChEMBL

PNG

BDBM50540150(CHEMBL3559961 | US10626094, Example I179 | US11220...)

IC50: 4.44E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540159(CHEMBL4642757)

IC50: 4.78E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540155(CHEMBL4634689)

IC50: 4.80E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 4.83E+3nMAssay Description:Inhibition of PDE7A1 catalytic domain (130 to 482 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair

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Amyloid-beta precursor protein(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50492607(CHEMBL2407101)

IC50: 5.80E+3nMAssay Description:Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence methodMore data for this Ligand-Target Pair

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Amyloid-beta precursor protein(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50492612(CHEMBL2408100)

IC50: 5.90E+3nMAssay Description:Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL

PNG

BDBM50540152(CHEMBL4638069)

IC50: 6.22E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 107 total ) | Next | Last >>

Filter my 107 hits

Targets 21▿
- Amyloid-beta precursor protein 27
- Acetylcholinesterase 16
- Cholinesterase 16
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 15
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 14
- NAD-dependent protein deacetylase sirtuin-1 3
- NAD-dependent protein deacetylase sirtuin-2 2
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- Potassium voltage-gated channel subfamily H member 2 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 1
- Cytochrome P450 1A2 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- Cytochrome P450 2C9 1
- Cytochrome P450 2D6 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1
- Cytochrome P450 2B6 1
- Cytochrome P450 3A4 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
- ...
Publications 5▿
- J Med Chem 62: 4218-4224 (2019) 43
- Bioorg Med Chem 28: (2020) 32
- Eur J Med Chem 66: 22-31 (2013) 27
- J Nat Prod 75: 2193-9 (2012) 4
- Bioorg Med Chem Lett 24: 349-52 (2013) 1
Institutions 3▿
- Sun Yat-Sen University 70
- Henan University 32
- San Francisco State University 5
Affinity: 8.7 to 4.5E+6 nM▿
- IC50 107
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 13