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Found 1087 with Last Name = 'chin' and Initial = 'dn'
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50261816(CHEMBL511749 | tert-butyl 4-(3-((7-(hydroxyamino)-...)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HDAC6 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267760(3-Benzofuran-3-yl-4-(7-methoxymethyl-1-methyl-1H-i...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267461(3-(5-Fluoro-1-methyl-1H-indol-3-yl)-4-(6-hydroxyme...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50261816(CHEMBL511749 | tert-butyl 4-(3-((7-(hydroxyamino)-...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of HDAC3 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267607(3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(6-hydroxymet...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267800(3-(6-Hydroxymethylbenzofuran-3-yl)-4-(7-methoxymet...)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267523(3-(6-Chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-...)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC6 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM191194(US9181266, 63)
Affinity DataIC50:  1nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267802(3-[3-(4-Benzofuran-3-yl-2,5-dioxo-2,5-dihydro-1H-p...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1.38nMAssay Description:Inhibition of HDAC8 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC3 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM191195(US9181266, 64)
Affinity DataIC50:  2.5nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50261753(5-(3-aminophenyl)-N-(7-(hydroxyamino)-7-oxoheptyl)...)
Affinity DataIC50:  2.54nMAssay Description:Inhibition of HDAC6 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50258646(CHEMBL468935 | N1-(4-(3-aminophenyl)thiazol-2-yl)-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50258645(CHEMBL511212 | N1-hydroxy-N8-(4-phenylthiazol-2-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50258645(CHEMBL511212 | N1-hydroxy-N8-(4-phenylthiazol-2-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185805(US9163003, 13 | USRE46942, Example 13)
Affinity DataIC50:  3nMT: 2°CAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185805(US9163003, 13 | USRE46942, Example 13)
Affinity DataIC50:  3nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of CDK9/cyclin T1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267520(3-(5-Fluoro-1-methyl-1H-indol-3-yl)-4-(6-hydroxybe...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50439791(CHEMBL2419706 | US9181266, 5)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50439799(CHEMBL2419698 | US9181266, 13)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of CDK5/P35More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50261752(CHEMBL469275 | tert-butyl 3-(3-((5-(hydroxyamino)-...)
Affinity DataIC50:  3.98nMAssay Description:Inhibition of HDAC6 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HDAC1 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50258646(CHEMBL468935 | N1-(4-(3-aminophenyl)thiazol-2-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK5/P25 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM191193(US9181266, 62)
Affinity DataIC50:  4nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50261753(5-(3-aminophenyl)-N-(7-(hydroxyamino)-7-oxoheptyl)...)
Affinity DataIC50:  4.04nMAssay Description:Inhibition of HDAC3 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM404370(2-{(S)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Affinity DataIC50:  5nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185818(US9163003, 30)
Affinity DataIC50:  5nMT: 2°CAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HDAC10 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50258647(CHEMBL512644 | N1-(biphenyl-4-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM191199(US9181266, 68)
Affinity DataIC50:  5nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267759(3-(6-Hydroxymethylbenzofuran-3-yl)-4-(7-hydroxymet...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50267758(3-Benzofuran-3-yl-4-(7-hydroxymethyl-1-methyl-1H-i...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50261818(5-(4-aminophenyl)-N-(7-(hydroxyamino)-7-oxoheptyl)...)
Affinity DataIC50:  5.86nMAssay Description:Inhibition of HDAC6 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185802(US9163003, 10 | USRE46942, Example 10)
Affinity DataIC50:  6nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185805(US9163003, 13 | USRE46942, Example 13)
Affinity DataIC50:  6nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185802(US9163003, 10 | USRE46942, Example 10)
Affinity DataIC50:  6nMT: 2°CAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM185805(US9163003, 13 | USRE46942, Example 13)
Affinity DataIC50:  6nMT: 2°CAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM191219(US9181266, 88)
Affinity DataIC50:  6nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50439791(CHEMBL2419706 | US9181266, 5)
Affinity DataIC50:  6nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In DepthDetails US Patent
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