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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50185007(CHEMBL3822686)

Ki: 14nMAssay Description:Mixed-type inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 15 mins followed by substrate addition by Dixon plot...More data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50448214(CHEMBL3120707)

Ki: 47nMAssay Description:Noncompetitive inhibition of electric eel AchE using acetylcholine as substrate preincubated for 15 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50381952(CHEMBL2022933)

Ki: 65nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50401238(CHEMBL2206895)

Ki: 81nMAssay Description:Mixed-type inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Acetylcholinesterase(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry (Iqog, Csic)

Curated by ChEMBL

BDBM50449738(CHEMBL4174958)

Ki: 147nMAssay Description:Non-competitive inhibition of recombinant human AChE expressed in HEK293 cells assessed as enzyme-substrate-inhibitor complex using varying levels of...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50359391(CHEMBL1929421)

Ki: 149nMAssay Description:Mixed type inhibition of Electrophorus electricus AchE using acetylthiocholine as substrate by Line-Weaver Burk plot analysisMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50384793(CHEMBL2037384)

Ki: 155nMAssay Description:Mixed type inhibition of electric eel AChE using acetylthiocholine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)

Ki: 428nMAssay Description:Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50357943(CHEMBL1916768)

Ki: 621nMAssay Description:Mixed-type inhibition of Electrophorus electricus AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Acetylcholinesterase(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry (Iqog, Csic)

Curated by ChEMBL

BDBM50449745(CHEMBL4171520)

Ki: 3.88E+3nMAssay Description:Non-competitive inhibition of recombinant human AChE expressed in HEK293 cells assessed as enzyme-substrate-inhibitor complex using varying levels of...More data for this Ligand-Target Pair

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PDB MMDB
UniProtKB/TrEMBL
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Carboxylic ester hydrolase(Equus caballus (Horse))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM50381961(CHEMBL2022928)

Ki: 7.10E+3nMAssay Description:Competitive inhibition of equine serum BChE using acetylthiocholine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM31904(CHEMBL345124 | Propidium | Propidium Iodide, 2 | p...)

Ki: 8.60E+3nMAssay Description:Binding affinity to Electrophorus electricus AChE peripheral anionic siteMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM31904(CHEMBL345124 | Propidium | Propidium Iodide, 2 | p...)

Ki: 8.90E+3nMAssay Description:Binding affinity to Electrophorus electricus AChE peripheral anionic siteMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50324068(2-Chloro-6-(piperidin-1-yl)pyridine-3,5-dicarbonit...)

Ki: 1.72E+4nMAssay Description:Non competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Amine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL

BDBM50381960(CHEMBL2022927)

IC50: 0.0250nMAssay Description:Inhibition of mitochondrial MAO-B in rat liver homogenates using [14C]-phenylethylamine as substrate preincubated for 30 mins by liquid scintillation...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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NACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Hospital Universitario Santa Cristina

Curated by ChEMBL

BDBM50605051(CHEMBL5184952)

IC50: 0.230nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in ATP induced IL-1beta release pretreated for 15 mi...More data for this Ligand-Target Pair

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NACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Hospital Universitario Santa Cristina

Curated by ChEMBL

BDBM50155926(CHEMBL3183703)

IC50: 0.390nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in ATP induced IL-1beta release pretreated for 15 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM50381960(CHEMBL2022927)

IC50: 0.790nMAssay Description:Inhibition of mitochondrial MAO-A in rat liver homogenates using [14C]-(5-hydroxy-triptamine) as substrate preincubated for 30 mins by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
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PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Laboratorio De Quimica Medica (Iqog, Csic)

Curated by ChEMBL

BDBM50087800((5-Benzyloxy-1H-indol-2-ylmethyl)-prop-2-ynyl-amin...)

IC50: 4.10nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 15 minsMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Amine oxidase [flavin-containing] A(Homo sapiens (Human))
Laboratorio De Quimica Medica (Iqog, Csic)

Curated by ChEMBL

BDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)

IC50: 4.70nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 15 minsMore data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
University Of Lisbon

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 5.20nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair

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Cholinesterase(Equus caballus (Horse))
University Of Lisbon

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 5.20nMAssay Description:Inhibition of horse serum BuChE by Ellman's methodMore data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM50359391(CHEMBL1929421)

IC50: 5.20nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Cholinesterase(Equus caballus (Horse))
University Of Lisbon

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 5.20nMAssay Description:Inhibition of Equus caballus BChE preincubated for 10 mins measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

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Carboxylic ester hydrolase(Equus caballus (Horse))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 5.20nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] A(Homo sapiens (Human))
Laboratorio De Quimica Medica (Iqog, Csic)

Curated by ChEMBL

BDBM50069802(CHEMBL3407581)

IC50: 6.30nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 15 minsMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)

IC50: 6.70nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate ...More data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM50359396(CHEMBL1929420 | US8999994, 5)

IC50: 6.70nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)

IC50: 6.70nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50448218(CHEMBL3120710)

IC50: 7nMAssay Description:Inhibition of electric eel AchE using acetylcholine as substrate preincubated for 15 mins followed by substrate addition measured for 5 mins by Ellma...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM36552(Prochelators, 2)

IC50: 7.70nMAssay Description:Inhibition of rat MAO-AMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Acetylcholinesterase(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry (Iqog, Csic)

Curated by ChEMBL

BDBM50391207(CHEMBL2088785)

IC50: 9.40nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine as substrate by Ellman methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM50359395(CHEMBL1929422)

IC50: 10nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Acetylcholinesterase(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry (Iqog, Csic)

Curated by ChEMBL

BDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)

IC50: 10nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine as substrate by Ellman methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50333148(5-Amino-2-(dimethylamino)-6,7,8,9-tetrahydrobenzo[...)

IC50: 14nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Acetylcholinesterase(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry (Iqog, Csic)

Curated by ChEMBL

BDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)

IC50: 16nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 minsMore data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Laboratorio De Quimica Medica (Iqog, Csic)

Curated by ChEMBL

BDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)

IC50: 18nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 15 minsMore data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL

BDBM50381959(CHEMBL2021938)

IC50: 22nMAssay Description:Inhibition of mitochondrial MAO-B in rat liver homogenates using [14C]-phenylethylamine as substrate preincubated for 30 mins by liquid scintillation...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50333150(5-Amino-2-piperidin-1-yl-6,7,8,9-tetrahydrobenzo[1...)

IC50: 25nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50381952(CHEMBL2022933)

IC50: 25nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 27nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 27nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by Ellman'...More data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 27nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)

IC50: 27nMAssay Description:Inhibition of electric eel AChE preincubated for 10 mins measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

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Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50381964(CHEMBL2022932)

IC50: 29nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair

Acetylcholinesterase(Electrophorus electricus (Electric eel))
University Complutense Madrid (Ucm)

Curated by ChEMBL

BDBM50333151(5-Amino-2-(prop-2-yn-1-ylamino)-6,7,8,9-tetrahydro...)

IC50: 30nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Curated by ChEMBL

BDBM50359392(CHEMBL1929424 | US8999994, 3)

IC50: 31nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Amine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL

BDBM50381961(CHEMBL2022928)

IC50: 31nMAssay Description:Inhibition of mitochondrial MAO-B in rat liver homogenates using [14C]-phenylethylamine as substrate preincubated for 30 mins by liquid scintillation...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Amine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL

BDBM50381958(CHEMBL2022926)