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Found 289 with Last Name = 'christie' and Initial = 'j'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288953(11'N-(3-bromobenzyl)spiro[dihydro[1,3]dioxolane-2,...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  10nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033369(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Affinity DataKi:  20nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  20nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288954(11-benzyl-11-azahexacyclo[5.4.1.02,6.03,10.04,8.09...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288949(11'N-(4-iodomobenzyl)spiro[dihydro[1,3]dioxolane-2...)
Affinity DataKi:  35nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  53nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288950(11'N-(3-iodobenzyl)spiro[dihydro[1,3]dioxolane-2,8...)
Affinity DataKi:  58nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  62nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288955(11'N-benzylspiro[dihydro[1,3]dioxolane-2,8'-pentac...)
Affinity DataKi:  79nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  86nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  92nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288952(11-(3-bromobenzyl)-11-azahexacyclo[5.4.1.02,6.03,1...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  124nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  134nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  224nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  304nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  365nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  419nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  698nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  1.53E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  1.76E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  2.57E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  3.78E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  4.16E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  5.61E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50113973(CHEMBL3605513)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418943(CHEMBL1807821)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418942(CHEMBL1807822)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50102692(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418944(CHEMBL1807819)
Affinity DataIC50:  4nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50396765(CHEMBL2172376)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PDE4D-mediated [3H]CAMP hydrolysis after 30 to 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418958(CHEMBL1807820)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418945(CHEMBL1807818)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418946(CHEMBL1807817)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50113976(CHEMBL3605510)
Affinity DataIC50:  8nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50113975(CHEMBL3605511)
Affinity DataIC50:  13nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50102692(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50396765(CHEMBL2172376)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PDE4B-mediated [3H]CAMP hydrolysis after 30 to 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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