TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataKi: 1.65E+3nMAssay Description:Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li...More data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataKi: 1.77E+3nMAssay Description:Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li...More data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataKi: 1.96E+4nMAssay Description:Mixed inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataKi: 2.01E+4nMAssay Description:Mixed inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using DHF as substrate measured every 30 secs over 6 mins by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human recombinant dihydrofolate reductase using dihydrofolate as substrate measured every 30 secs over 6 mins by UV/visible spectrophot...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 10.1nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
Affinity DataIC50: 11.2nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
Affinity DataIC50: 13.3nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 13.8nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair