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Found 257 with Last Name = 'chui' and Initial = 'wk'
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50004462(CHEMBL3233329)
Affinity DataKi:  1.65E+3nMAssay Description:Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50004460(CHEMBL3233327)
Affinity DataKi:  1.77E+3nMAssay Description:Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50439105(CHEMBL2418061)
Affinity DataKi:  1.96E+4nMAssay Description:Mixed inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50439106(CHEMBL2418074)
Affinity DataKi:  2.01E+4nMAssay Description:Mixed inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM82109(6,8,10-Traiazaspiro[4.5]deca-6,8-diene-7,9-diamine...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM82109(6,8,10-Traiazaspiro[4.5]deca-6,8-diene-7,9-diamine...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236320(CHEMBL4091106)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236287(CHEMBL4071967)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236288(CHEMBL4098945)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50211072(CHEMBL3974488)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236325(CHEMBL4099755)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236291(CHEMBL4060570)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50211070(CHEMBL3943671)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236289(CHEMBL4082453)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236319(CHEMBL4101407)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236324(CHEMBL4080801)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348449(CHEMBL1801203)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236323(CHEMBL4070144)
Affinity DataIC50:  6.10nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348446(CHEMBL1801200)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236286(CHEMBL4079985)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50211069(CHEMBL3952384)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM82116(1,3,5-Triazaspiro[5.5]undeca-1,3-diene-2,4-diamine...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM82116(1,3,5-Triazaspiro[5.5]undeca-1,3-diene-2,4-diamine...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using DHF as substrate measured every 30 secs over 6 mins by spect...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348433(CHEMBL1800939)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50211066(CHEMBL3931887)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348438(CHEMBL1800944)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50290152(CHEMBL526013)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant dihydrofolate reductase using dihydrofolate as substrate measured every 30 secs over 6 mins by UV/visible spectrophot...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50211067(CHEMBL3965885)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50290152(CHEMBL526013)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348434(CHEMBL1800940)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236285(CHEMBL4098009)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236284(CHEMBL4069255)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348439(CHEMBL1800945)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM82114(1,3,5-Triazaspiro[5.5]undeca-1,3-diene-2,4-diamine...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348435(CHEMBL1800941)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348447(CHEMBL1801201)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  10nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348451(CHEMBL1800938)
Affinity DataIC50:  10.1nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50211073(CHEMBL3912587)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human DHFR using DHF as substrate measured every 5 sec over 6 mins in presence of NADPH by UV-Visible spectrophotometric me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348437(CHEMBL1800943)
Affinity DataIC50:  11.2nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236290(CHEMBL4083419)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348448(CHEMBL1801202)
Affinity DataIC50:  13.3nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50348442(CHEMBL1800948)
Affinity DataIC50:  13.8nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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