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Found 1595 with Last Name = 'clare' and Initial = 'm'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036257(((S)-1-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-butyl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50010495(Acetyl-Ser-Leu-Asn-Phe-[CH(OH)CH2N]Pro-Ile-Val-OMe...)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity of the compound against HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036261((S)-N*1*-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-but...)
Affinity DataKi:  1nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036251(CHEMBL141265 | [(1S,2R)-3-(Benzenesulfonyl-isobuty...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036252(CHEMBL347671 | {(1S,2R)-1-Benzyl-3-[(4-chloro-benz...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036262(CHEMBL348282 | [(1S,2R)-3-(Benzenesulfonyl-cyclohe...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036253(CHEMBL347431 | {(1S,2R)-3-[Benzenesulfonyl-(3-meth...)
Affinity DataKi:  10nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036259((S)-N*1*-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesul...)
Affinity DataKi:  13nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50010497(Acetyl-Ser-Leu-Asn-Phe-[S]-[CH(OH)CH2N]Pro-Ile-Val...)
Affinity DataKi:  20nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measured (exp 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50010497(Acetyl-Ser-Leu-Asn-Phe-[S]-[CH(OH)CH2N]Pro-Ile-Val...)
Affinity DataKi:  20nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036258(((S)-1-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesulfo...)
Affinity DataKi:  57nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036260(CHEMBL156424 | {(1S,2R)-1-Benzyl-3-[(3-chloro-benz...)
Affinity DataKi:  61nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036255(CHEMBL154197 | [(1S,2R)-3-(Benzenesulfonyl-benzyl-...)
Affinity DataKi:  125nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036254(CHEMBL155051 | {(1S,2R)-1-Benzyl-2-hydroxy-3-[(3-m...)
Affinity DataKi:  128nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036264(CHEMBL154600 | {(1S,2R)-1-Benzyl-3-[(2-chloro-benz...)
Affinity DataKi:  227nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156071(3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]-MPEP from human mGluR5More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036263(CHEMBL154638 | {(1S,2S)-3-[Benzenesulfonyl-(3-meth...)
Affinity DataKi:  295nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50133557(1-[2-(2,6-Dichloro-benzyl)-thiazol-4-yl]-3-morphol...)
Affinity DataKi:  500nMAssay Description:Inhibition of Tau Protein Kinase II (TPK II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036256(CHEMBL154798 | {(1S,2R)-1-Benzyl-2-hydroxy-3-[meth...)
Affinity DataKi:  1.87E+3nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331975(1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(p...)
Affinity DataKi:  2.37E+3nMAssay Description:Displacement of [3H]-MPEP from human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Searle

Curated by ChEMBL
LigandPNGBDBM50453625(CHEMBL2110229)
Affinity DataIC50:  0.100nMAssay Description:Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Searle

Curated by ChEMBL
LigandPNGBDBM50036787(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Searle

Curated by ChEMBL
LigandPNGBDBM50036787(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Searle

Curated by ChEMBL
LigandPNGBDBM50453625(CHEMBL2110229)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177621((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(4-(4-thiomo...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
Oxalurx

US Patent
LigandPNGBDBM581194(5-(4-(2-(3-chlorophenyl) ethynyl)phenoxy)-1H-1,2,...)
Affinity DataIC50:  0.300nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177626(3-(benzo[d]oxazol-6-yl)-4-(3-(3-(5,6,7,8-tetrahydr...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177628((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(3-(5,6,7,8-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
Oxalurx

US Patent
LigandPNGBDBM581193(5-(4-(2-(4-chlorophenyl) ethynyl)phenoxy)-1H-1,2,...)
Affinity DataIC50:  0.400nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209124((2,2-dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209124((2,2-dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209124((2,2-dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor by solid phase receptor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209132((2-{3-fluoro-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyr...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor by solid phase receptor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209131(4-[3-(2-N-pyridyl)amino]-1-propyloxyphenyl-3-(3-py...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor by solid phase receptor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177626(3-(benzo[d]oxazol-6-yl)-4-(3-(3-(5,6,7,8-tetrahydr...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209121((2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor by solid phase receptor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177629(3-(2-cyclopropylthiazol-5-yl)-4-(3-(3-(5,6,7,8-tet...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209121((2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177621((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(4-(4-thiomo...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177618(3-(2,3-dihydrobenzofuran-6-yl)-4-(3-(3-(5,6,7,8-te...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177628((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(3-(5,6,7,8-...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177636(3-(quinolin-3-yl)-4-(3-(3-(5,6,7,8-tetrahydro-1,8-...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177616((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(4-(4-morpho...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177622(3-(pyridin-3-yl)-4-(3-(3-(5,6,7,8-tetrahydro-1,8-n...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177616((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(4-(4-morpho...)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of cathepsin E using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209120((2-{3-hydroxy-4-[2-(5,6,7,8-tetrahydro-1,8-naphthy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human intergrin alphavbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Searle

Curated by ChEMBL
LigandPNGBDBM50453616(CHEMBL2110337)
Affinity DataIC50:  0.920nMAssay Description:Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
Oxalurx

US Patent
LigandPNGBDBM581199(5-(3-(2-(2-methylpyridin-4- yl)ethynyl)phenoxy)-1...)
Affinity DataIC50:  1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
Oxalurx

US Patent
LigandPNGBDBM581192(5-(3-(2-(4-fluorophenyl) ethynyl)phenoxy)-1H-1,2,...)
Affinity DataIC50:  1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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