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Found 677 with Last Name = 'cockcroft' and Initial = 'x'
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
School Of Natural Sciences--Chemistry

Curated by ChEMBL
LigandPNGBDBM50156495(8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chro...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory activity against DNA-dependent protein kinase receptorMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090249(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  6nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090249(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  6nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077057(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  24nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077058(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  26nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077058(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  26nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090222(CHEMBL39086 | MD805 Analogue)
Affinity DataKi:  26nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090244(3,3-Dimethyl-6-[3-oxo-3-(4-pyridin-4-ylmethyl-pipe...)
Affinity DataKi:  27nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090222(CHEMBL39086 | MD805 Analogue)
Affinity DataKi:  28nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090247(6-[3-(4-Acetyl-piperazin-1-yl)-3-oxo-propyl]-3,3-d...)
Affinity DataKi:  34nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090250(3-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  34nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077049(CHEMBL24186 | Methyl-carbamic acid 2-{1-[(S)-3-ben...)
Affinity DataKi:  38nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090243(6-(2-Hydroxy-ethyl)-3,3-dimethyl-1,2,3,4-tetrahydr...)
Affinity DataKi:  39nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090246(3,3-Dimethyl-6-(2-ureido-ethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  47nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077053((2-{1-[(S)-3-Benzothiazol-2-yl-2-(3,3-dimethyl-1,2...)
Affinity DataKi:  52nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077044((2-{1-[(S)-3-Benzothiazol-2-yl-2-(3,3-dimethyl-1,2...)
Affinity DataKi:  56nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090238(3,3-Dimethyl-6-{3-[4-(2-morpholin-4-yl-2-oxo-ethyl...)
Affinity DataKi:  57nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090245(6-Hydroxymethyl-3,3-dimethyl-1,2,3,4-tetrahydro-qu...)
Affinity DataKi:  64nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077043(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  65nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090248(CHEMBL43397 | Methyl-carbamic acid 8-{(S)-1-benzot...)
Affinity DataKi:  77nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077056(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  79nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090241(3-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  82nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077042(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  93nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090242(4-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  94nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090226(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  118nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090226(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  118nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090253(6-(3-Hydroxy-propyl)-3,3-dimethyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  119nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077052(1N-(2-{1-[3-benzo[d][1,3]thiazol-2-yl-2-(3,3-dimet...)
Affinity DataKi:  119nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090251(6-(2-Methoxy-ethoxymethoxymethyl)-3,3-dimethyl-1,2...)
Affinity DataKi:  125nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50366643(CHEMBL1907778)
Affinity DataKi:  126nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077046(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  182nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077050(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  240nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090231(CHEMBL39375 | MD805 Analogue)
Affinity DataKi:  248nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50366642(CHEMBL1907779)
Affinity DataKi:  280nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077047(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  350nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090240(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro-et...)
Affinity DataKi:  359nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090236(CHEMBL418248 | MD805 Analogue)
Affinity DataKi:  452nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090239((8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro-e...)
Affinity DataKi:  500nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077051(CHEMBL28272 | N-(2-{1-[(S)-3-Benzothiazol-2-yl-2-(...)
Affinity DataKi:  654nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090252(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro-et...)
Affinity DataKi:  723nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090235(CHEMBL38907 | MD805 Analogue)
Affinity DataKi:  760nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090237(CHEMBL43074 | MD805 Analogue)
Affinity DataKi:  780nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090220(CHEMBL289623 | MD805 Analogue)
Affinity DataKi:  810nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077054(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077048(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50366643(CHEMBL1907778)
Affinity DataKi:  1.32E+3nMAssay Description:Compound was evaluated for its inhibitory activity against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090234(CHEMBL40904 | MD805 Analogue)
Affinity DataKi:  1.57E+3nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50366642(CHEMBL1907779)
Affinity DataKi:  1.78E+3nMAssay Description:Compound was evaluated for its inhibitory activity against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090230(CHEMBL38617 | MD805 Analogue)
Affinity DataKi:  2.19E+3nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090224(CHEMBL289493 | MD805 Analogue)
Affinity DataKi:  3.10E+3nMAssay Description:Compound was evaluated for its inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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