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Found 230 with Last Name = 'corman' and Initial = 'm'
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity of the compound against [125I]-Try0-o-Corticotropin-releasing Factor to Corticotropin releasing hormone receptor 1 from ovineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477060(CHEMBL393761)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477067(CHEMBL237875)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477038(CHEMBL237850)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477048(CHEMBL236597)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477051(CHEMBL237666)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477065(CHEMBL236592)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477046(CHEMBL236595)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477022(CHEMBL236594)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477040(CHEMBL237665)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477037(CHEMBL237867)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.370nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31591(pyrazole, 3)
Affinity DataIC50:  0.420nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477021(CHEMBL236596)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477061(CHEMBL393401)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM31606(methyl substituted pyrazole, 27)
Affinity DataIC50:  0.790nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477041(CHEMBL393397)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397844(CHEMBL2179099)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31594(substituted pyrazole, 11)
Affinity DataIC50:  0.920nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477050(CHEMBL236775)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397850(CHEMBL2179093)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477056(CHEMBL236773)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397845(CHEMBL2177125)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477047(CHEMBL240700)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477050(CHEMBL236775)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM31605(methyl substituted pyrazole, 26)
Affinity DataIC50:  1.29nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477069(CHEMBL240068)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  1.41nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31593(substituted pyrazole, 10)
Affinity DataIC50:  1.54nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477057(CHEMBL237669)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397848(CHEMBL2179096)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300113(1-cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300113(1-cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300112(CHEMBL565667 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300112(CHEMBL565667 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477027(CHEMBL392759)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477052(CHEMBL240066)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477068(CHEMBL236790)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477042(CHEMBL236774)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477055(CHEMBL241350)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477063(CHEMBL393756)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477063(CHEMBL393756)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477047(CHEMBL240700)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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