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Found 314 with Last Name = 'crabbe' and Initial = 't'
LigandPNGBDBM50264777(6,6-dimethyl-2-(6-(6-methylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265362(2-(6-(1-(3-aminopropyl)-3-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265318(6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyraz...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265317(2-(6-(1-benzyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]ox...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264873(6,6-dimethyl-2-(6-(6-phenylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264872(2-(6-(6-methoxypyridazin-3-ylamino)-2H-benzo[b][1,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265319(2-(6-(1,3-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264748((R)-2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083638((S)-4-(6-(3-methylpiperazin-1-yl)pyridin-3-yl)-N-(...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264871(2-(6-(6-(dimethylamino)pyridazin-3-ylamino)-2H-ben...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265282(2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol-4-y...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265364((S)-2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265280(2-(6-(1-ethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxa...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262174(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265319(2-(6-(1,3-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264777(6,6-dimethyl-2-(6-(6-methylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50261783(5,5-dimethyl-2-(6-(pyridin-3-yl)-2,3-dihydrobenzo[...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264872(2-(6-(6-methoxypyridazin-3-ylamino)-2H-benzo[b][1,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50261838(6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihyd...)
Affinity DataIC50:  21nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264749(6,6-dimethyl-2-(6-(6-(piperazin-1-yl)pyridazin-3-y...)
Affinity DataIC50:  21nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI3K gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264777(6,6-dimethyl-2-(6-(6-methylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  23nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264871(2-(6-(6-(dimethylamino)pyridazin-3-ylamino)-2H-ben...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264777(6,6-dimethyl-2-(6-(6-methylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083649(CHEMBL112518 | {4-[6-(3-Methyl-piperazin-1-yl)-pyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50261839(5,5-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihyd...)
Affinity DataIC50:  26nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50261838(6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihyd...)
Affinity DataIC50:  28nMAssay Description:Inhibition of PI3K gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265283(2-(6-(1-(3-(dimethylamino)propyl)-1H-pyrazol-4-yl)...)
Affinity DataIC50:  29nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264750(6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyrid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083640(CHEMBL112172 | [4-(6-[1,4]Diazepan-1-yl-pyridin-3-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265243(2-(6-(3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262224(6,6-dimethyl-2-(6-(1-methyl-1H-pyrazol-4-yl)-2,3-d...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262224(6,6-dimethyl-2-(6-(1-methyl-1H-pyrazol-4-yl)-2,3-d...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264873(6,6-dimethyl-2-(6-(6-phenylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264749(6,6-dimethyl-2-(6-(6-(piperazin-1-yl)pyridazin-3-y...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262460((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-5,5-di...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264750(6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyrid...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265318(6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyraz...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265363(2-(6-(5-amino-1-methyl-1H-pyrazol-4-yl)-2H-benzo[b...)
Affinity DataIC50:  36nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265361(2-(6-(1-(2-aminoethyl)-1H-pyrazol-4-yl)-2H-benzo[b...)
Affinity DataIC50:  39nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265281(2-(6-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)-2H-ben...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265316(6,6-dimethyl-2-(6-(1,3,5-trimethyl-1H-pyrazol-4-yl...)
Affinity DataIC50:  45nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083648(CHEMBL420672 | {4-[6-(4-Methyl-piperazin-1-yl)-pyr...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265364((S)-2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol...)
Affinity DataIC50:  46nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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