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Found 95 with Last Name = 'cripps' and Initial = 's'
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317213((2R)-N-(adamantan-2-yl)-1-(cyclopentylmethyl)pyrro...)
Affinity DataKi:  1nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317218((2R)-N-(adamantan-2-yl)-1-(3,3,3-trifluoropropyl)p...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317223((2R)-N-(adamantan-2-yl)-1-(pyridin-2-yl)pyrrolidin...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317217((2R)-N-(adamantan-2-yl)-1-(2,2,2-trifluoroethyl)py...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29864(N-(Pyridin-2-yl) arylsulfonamide, 26)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317221((2R)-N-(adamantan-2-yl)-1-[(3-cyanophenyl)methyl]p...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317211((2R)-N-(adamantan-2-yl)-1-propylpyrrolidine-2-carb...)
Affinity DataKi:  1nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317224((2R)-N-(adamantan-2-yl)-1-(oxan-4-ylmethyl)pyrroli...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209((2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carbo...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317211((2R)-N-(adamantan-2-yl)-1-propylpyrrolidine-2-carb...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317212((2R)-N-(adamantan-2-yl)-1-(propan-2-yl)pyrrolidine...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29863(N-(Pyridin-2-yl) arylsulfonamide, 25)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29862(N-(Pyridin-2-yl) arylsulfonamide, 24)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317219((2R)-N-(adamantan-2-yl)-1-[(4-chlorophenyl)methyl]...)
Affinity DataKi:  2nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317216((2R)-N-(adamantan-2-yl)-1-(cyclohexylmethyl)pyrrol...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317210((2R)-N-(adamantan-2-yl)-1-methylpyrrolidine-2-carb...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317208(CHEMBL1088115 | N-(adamantan-2-yl)-2-[cyclohexyl(e...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317216((2R)-N-(adamantan-2-yl)-1-(cyclohexylmethyl)pyrrol...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317218((2R)-N-(adamantan-2-yl)-1-(3,3,3-trifluoropropyl)p...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317222((2R)-N-(adamantan-2-yl)-1-(2-hydroxyethyl)pyrrolid...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29860(N-(Pyridin-2-yl) arylsulfonamide, 22)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29866(N-(Pyridin-2-yl) arylsulfonamide, 28)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317210((2R)-N-(adamantan-2-yl)-1-methylpyrrolidine-2-carb...)
Affinity DataKi:  5.40nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29858(N-(Pyridin-2-yl) arylsulfonamide, 20)
Affinity DataKi:  5.80nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317219((2R)-N-(adamantan-2-yl)-1-[(4-chlorophenyl)methyl]...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29861(N-(Pyridin-2-yl) arylsulfonamide, 23)
Affinity DataKi:  6.60nM ΔG°:  -46.2kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317212((2R)-N-(adamantan-2-yl)-1-(propan-2-yl)pyrrolidine...)
Affinity DataKi:  9.40nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29865(N-(Pyridin-2-yl) arylsulfonamide, 27)
Affinity DataKi:  9.80nM ΔG°:  -45.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317207(CHEMBL1088517 | N-cyclohexyl-2-(7,8-dihydro-4H-iso...)
Affinity DataKi:  15nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317224((2R)-N-(adamantan-2-yl)-1-(oxan-4-ylmethyl)pyrroli...)
Affinity DataKi:  16nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317225((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclopentyl)m...)
Affinity DataKi:  17nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29857(N-(Pyridin-2-yl) arylsulfonamide, 19)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317217((2R)-N-(adamantan-2-yl)-1-(2,2,2-trifluoroethyl)py...)
Affinity DataKi:  35.2nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317223((2R)-N-(adamantan-2-yl)-1-(pyridin-2-yl)pyrrolidin...)
Affinity DataKi:  40nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29856(N-(Pyridin-2-yl) arylsulfonamide, 18)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317226((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclohexyl)me...)
Affinity DataKi:  48nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29859(N-(Pyridin-2-yl) arylsulfonamide, 21)
Affinity DataKi:  62nM ΔG°:  -40.7kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29854(N-(Pyridin-2-yl) arylsulfonamide, 16)
Affinity DataKi:  84nM ΔG°:  -40.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29850(N-(Pyridin-2-yl) arylsulfonamide, 12)
Affinity DataKi:  108nM ΔG°:  -39.4kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29843(N-(Pyridin-2-yl) arylsulfonamide, 3)
Affinity DataKi:  169nM ΔG°:  -38.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29849(N-(Pyridin-2-yl) arylsulfonamide, 11)
Affinity DataKi:  169nM ΔG°:  -38.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317221((2R)-N-(adamantan-2-yl)-1-[(3-cyanophenyl)methyl]p...)
Affinity DataKi:  170nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317206((3-Phenyl-adamantan-1-yl)-piperidin-1-yl-methanone...)
Affinity DataKi:  175nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29841(N-(Pyridin-2-yl) arylsulfonamide, 1)
Affinity DataKi:  287nM ΔG°:  -37.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317206((3-Phenyl-adamantan-1-yl)-piperidin-1-yl-methanone...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 11-beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317215((2R)-N-(adamantan-2-yl)-1-(cyclobutylmethyl)pyrrol...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317220((2R)-N-(adamantan-2-yl)-1-[(4-cyanophenyl)methyl]p...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317226((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclohexyl)me...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317213((2R)-N-(adamantan-2-yl)-1-(cyclopentylmethyl)pyrro...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317214((2R)-N-(adamantan-2-yl)-1-(2-methylpropyl)pyrrolid...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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